Banca de QUALIFICAÇÃO: LUANA CAMILLA CORDEIRO BRAZ

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : LUANA CAMILLA CORDEIRO BRAZ
DATE: 30/11/2023
TIME: 14:00
LOCAL: Google Meet
TITLE:

Development of pipelines for prospecting plant bioactive peptides with  antithrombotic effects

KEY WORDS:

Molecular Mimicry; Anticoagulant; Thrombin Inhibitor; Viridiplantae; Plant  antithrombotics; Bioinformatics.

PAGES: 37
BIG AREA: Ciências Biológicas
AREA: Biologia Geral
SUMMARY:

Plants offer a vast potential as a source of active substances, allowing for the  incorporation of many extracts or purified substances into modern therapeutic  practices. The isolation of peptides, small amino acid polymers, with biological  activity has sparked interest in potential pharmaceutical or nutraceutical  applications. Several databases and pipelines are available and dedicated to  organizing information and discovering new peptides. Computational methods  have been developed to turn process of discovering potential candidates faster  and easyer. Cardiovascular diseases are the leading cause of death worldwide,  often requiring the use of antithrombotic drugs in treatment. The development  of new antithrombotics is necessary to address the limitations of available  therapies and provide more effective treatments for patients. Thus, this project  aims to develop a pipeline for prospecting new bioactive peptides of plant  origin and evaluating candidate peptides for antithrombotic activity, based on  the mechanisms of action of known peptides. The pipeline is being developed in  Python code, shared on GitHub, and integrates information from the CATH  structural domain database, an essential step for searching for peptides with  possible molecular mimicry. As part of the methodology, a case study was  conducted using a 6-amino acid antithrombotic peptide from peanuts. Results  identified 25 new candidates with potential anticoagulant activity. These  peptides were ranked based on comparison with the peanut sequence using  scores from the BLOSUM62 similarity matrix. Among future prospects, we aim to  analyze the peptides found for their interaction with biological targets.  Additionally, we intend to continue developing the pipeline to create an easily  configurable and usable tool for searching for new bioactive plant peptides.

COMMITTEE MEMBERS:
Interno - 1513597 - JOAO PAULO MATOS SANTOS LIMA
Presidente - ***.117.554-** - THAIS GAUDENCIO DO REGO - UFPB
Interno - ***.739.204-** - VINICIUS RAMOS HENRIQUES MARACAJA COUTINHO - USP