Banca de DEFESA: JOSIVAN RIBEIRO JUSTINO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : JOSIVAN RIBEIRO JUSTINO
DATE: 16/09/2021
TIME: 08:00
LOCAL: meet.google.com/uvi-ckzo-msi
TITLE:

MODEL FOR IDENTIFYING BIMODAL GENES ASSOCIATED WITH CANCER PROGNOSIS

KEY WORDS:

cancer; gene expression; bimodal distribution; Gaussian Mixture Model; survival analysis.

 

PAGES: 65
BIG AREA: Ciências Biológicas
AREA: Genética
SUMMARY:

In the last decades, the biological interest in understanding the phases of gene regulation has led to the discovery of tumor genes with differentiated expression in subgroups of patients. These genes have a bimodal profile of expression value distribution, which has raised attention to investigate the patterns of development and their functionality. A major limitation of traditional methods is to identify homogeneous subgroups representing distinct levels of gene expression value for the same tumor. We developed a method that selects candidate genes for the bimodality pattern from the probability density function of the expression values, allowing to minimize the internal heterogeneity of the peaks. We analyzed 25 tumor types, found 96 genes with consistent samples regarding survival prognosis with a p-value ≤ 0.01. As a contribution, we have a method with the free code, which makes it possible to reduce the levels of internal variability of the groups and which relates the bimodal expression pattern with survival prognosis. Thus, we believe that the use of the method may be useful in the evaluation of the bimodal pattern of gene expression and in the discovery of new clinical biomarkers for different types of cancer.

BANKING MEMBERS:
Externa à Instituição - Giovana Torrezan
Interno - 2170415 - JORGE ESTEFANO SANTANA DE SOUZA
Externo ao Programa - 1066308 - MARCUS ALEXANDRE NUNES
Presidente - 1939184 - SANDRO JOSE DE SOUZA
Externo à Instituição - ÂNDREA KELY CAMPOS RIBEIRO DOS SANTOS - UFPA