Banca de QUALIFICAÇÃO: IARA DANTAS DE SOUZA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : IARA DANTAS DE SOUZA
DATE: 28/11/2019
TIME: 09:00
LOCAL: BioME - PPg-Bioinfo
TITLE:

Evolutionary analysis of essential genes in eukaryotic model organisms

KEY WORDS:

Essential genes, cluster of orthologous groups, geneplast, model organisms, network properties, systems evolution.

PAGES: 42
BIG AREA: Ciências Biológicas
AREA: Biologia Geral
SUMMARY:

Genes crucial for cellular maintenance are called essential genes. They participate in cell core functions and deleterious mutations on those genes result in lethality. In multicellular organisms, deleterious alterations on essential genes produce a spectrum of phenotypes, from the impairment of fertilization process, disruption of fetal development, up to loss of reproductive capacity in adult individuals. We suppose that considering the importance of processes regulated by essential genes, they arose earlier during the evolutionary history and were conserved in many organisms. Here we aim to identify the essential genes in eukaryotic organisms and estimate their evolutionary root as well as their network properties. We retrieved phenotype information of mutant genotypes from specialized model organism databases. Based on whether the mutant genotype can be lethal, we classified genes in essential and other genes. We have identified the orthologous groups belonging to essential and non-essential genes with STRING database (v11). Using the geneplast R package, we inferred the evolutionary root of essential and other genes. We observed that essential genes, in average, are older than other genes in all organisms considered. The network properties in terms of gene essentiality seem to be specific to each organism considered. All exclusive essential COGs are younger than the shared essential COGs, with the latter prevailing in the initial branches of each organism phylogenetic tree.

BANKING MEMBERS:
Interno - 2170415 - JORGE ESTEFANO SANTANA DE SOUZA
Externa ao Programa - 1365498 - BEATRIZ STRANSKY FERREIRA