Banca de DEFESA: PEDRO IGOR CÂMARA DE OLIVEIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : PEDRO IGOR CÂMARA DE OLIVEIRA
DATA : 07/06/2019
HORA: 14:00
LOCAL: Auditório b206, IMD
TÍTULO:

Planning new Trypanosoma cruzi CYP51 inhibitors using QSAR studies

PALAVRAS-CHAVES:

QSAR; Trypanosoma cruzi; CYP51; Structure-based drug design; Chagas disease. 

PÁGINAS: 42
GRANDE ÁREA: Ciências Biológicas
ÁREA: Biologia Geral
RESUMO:

Chagas disease kills over 10,000 people per year and approximately 8 million people are infected by Trypanosoma cruzi. The reference drug for treatment of the disease, benznidazole, is the same since the 70s. In recent years, many CYP51 inhibitors were tested against this parasite’s target. One of them, posaconazole, was even tested in clinical trials that unfortunately were not successful. Nevertheless, there are still many evidences that CYP51 is a great potential target to treat T. cruzi infection.  The research for new effective molecules that can cure the chronic phase of the disease is essential. 2D and 3D-Quantitative Structure Activity Relationship (QSAR) studies were conducted in this work to create three QSAR models using the chemical structures of 197 published compounds that already went through either in vivo or in vitro tests. After the analysis of the models, new analogues not yet synthesized were suggested here and had their biological activity and synthetic availability assessed. 

MEMBROS DA BANCA:
Presidente - 1893445 - EUZEBIO GUIMARAES BARBOSA
Externo à Instituição - MARCUS TULLIUS SCOTTI - UFPB
Externo ao Programa - 1752367 - PAULO MARCOS DA MATTA GUEDES