Banca de DEFESA: ANA CAROLINA MIRANDA FERNANDES COÊLHO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : ANA CAROLINA MIRANDA FERNANDES COÊLHO
DATA : 18/04/2019
HORA: 13:30
LOCAL: BioME - PPg-Bioinfo
TÍTULO:

neoANT-HILL: an integrated tool for identification of potential neoantigens

PALAVRAS-CHAVES:

neoantigens; cancer; somatic mutations; T cells; HLA molecules; immunogenomics analyses.

PÁGINAS: 50
GRANDE ÁREA: Ciências Biológicas
ÁREA: Biologia Geral
RESUMO:

In recent years, neoantigens have generated great interest in immunotherapy due to its ability to elicit antitumor immune responses. Neoantigens arise from specific somatic mutations and it can be present by HLA molecules on the surface of tumor cells and recognized by T cells as non-self molecules. Several studies have indicated promising results in the use of neoantigens in different immunotherapeutic approaches. However, the precise identification of neoantigens remains challenging. Therefore, the aim of the present work was developing a computational tool that integrates the individual immunogenetics analyses, which are fundamental for the identification of potential neoantigens. RNA-seq data from GEUVADIS project and melanoma mutation data obtained from the TCGA to validate the developed pipeline. As a result, we developed a tool, called neoANT-HILL, in Python programming language and available through a friendly and interactive graphical user interface. Data from the whole genome or exome sequencing and/or RNA-Seq data are used for performing the immunogenomic analyzes. The integration of the results allows the identification of potential neoantigens candidates for immunotherapy.

MEMBROS DA BANCA:
Interno - 2170415 - JORGE ESTEFANO SANTANA DE SOUZA
Presidente - 1939184 - SANDRO JOSE DE SOUZA
Externa à Instituição - ÂNDREA KELY CAMPOS RIBEIRO DOS SANTOS - UFPA