Banca de QUALIFICAÇÃO: ANDRE LUIS FONSECA FAUSTINO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : ANDRE LUIS FONSECA FAUSTINO
DATA : 04/09/2018
HORA: 09:00
LOCAL: BioME
TÍTULO:

Bioinformatics Analysis of the Human Surfaceome Reveals New Targets for a Variety of Tumor Types

PALAVRAS-CHAVES:

Cell surface receptors. Cancer prognosis and treatment. Drug-targets and precise medicine.

PÁGINAS: 8
GRANDE ÁREA: Ciências Biológicas
ÁREA: Biologia Geral
RESUMO:

It is estimated that 10 to 20% of all genes in the human genome encode cell surface proteins and due to their subcellular localization these proteins represent excellent targets for cancer diagnosis and therapeutics. Therefore, a precise characterization of the surfaceome set in different types of tumor is needed. Using TCGA data from 15 different tumor types and a new method to identify cancer genes, the S-score, we identified several potential therapeutic targets within the surfaceome set. This allowed us to expand a previous analysis from us and provided a clear characterization of the human surfaceome in the tumor landscape. Moreover, we present evidence that a three-gene set - WNT5A, CNGA2, and IGSF9B - can be used as a signature associated with shorter survival in breast cancer patients. The data made available here will help the community to develop more efficient diagnostic and therapeutic tools for a variety of tumor types.

MEMBROS DA BANCA:
Presidente - 1939184 - SANDRO JOSE DE SOUZA
Interno - 1267860 - GUSTAVO ANTONIO DE SOUZA
Externo ao Programa - 1365498 - BEATRIZ STRANSKY FERREIRA