Banca de DEFESA: IARA DANTAS DE SOUZA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : IARA DANTAS DE SOUZA
DATA : 14/12/2017
HORA: 09:00
LOCAL: INSTITUTO METRÓPOLE DIGITAL - SALA B206
TÍTULO:

LEAD POISONING METABOLIC MAP

PALAVRAS-CHAVES:

Lead is an important heavy metal used worldwide in several applications, especially in industry. People exposed to lead can develop a wide range of symptoms associated with lead poisoning. Many effects of lead poisoning were reported in the literature, showing a compromising of whole body health, with symptoms related to cardiovascular, immune, bone, reproductive, hematological, renal, gastrointestinal, and nervous system. However, the molecular lead targets as well as the pathways affected by lead poisoning are not completely described. The aim of this study was to construct a map of metabolic pathways impaired in lead poisoning by evaluating which biomolecules are directly affected by lead. Through manual literature curation, we identified proteins which physically interact with lead and subsequently determined the metabolic pathways those proteins are involved with. At total, we identified 23 proteins involved with heme synthesis, calcium metabolism, neurotransmission, among other biological systems, which helps to understand the wide range of lead poisoning symptoms.

PÁGINAS: 81
GRANDE ÁREA: Ciências Biológicas
ÁREA: Bioquímica
RESUMO:

Lead is an important heavy metal used worldwide in several applications, especially in industry. People exposed to lead can develop a wide range of symptoms associated with lead poisoning. Many effects of lead poisoningwere reported in the literature, showing a compromising of whole body health, with symptoms related to cardiovascular, immune, bone, reproductive, hematological, renal, gastrointestinal, and nervous system. However, the molecular lead targets as wellas the pathways affected by lead poisoning are not completely described. The aim of this study was to construct a map of metabolic pathways impaired in lead poisoning byevaluating which biomolecules are directly affected by lead. Through manual literature curation, we identified proteins which physically interact with lead and subsequently determined the metabolic pathways those proteins are involved with. At total, weidentified 23 proteins involved with heme synthesis, calcium metabolism, neurotransmission, among other biological systems, which helps to understand the wide range of lead poisoning symptoms.

MEMBROS DA BANCA:
Interno - 1513597 - JOAO PAULO MATOS SANTOS LIMA
Externo à Instituição - MAURO ANTONIO ALVES CASTRO - UFPR
Presidente - 1507794 - RODRIGO JULIANI SIQUEIRA DALMOLIN
Externo ao Programa - 1674709 - VIVIANE SOUZA DO AMARAL