Introduction: A notification of patient safety incidents needs to be encouraged in health organizations in order to support the identification and analysis of the systemic causes of failures in the care process, generating learning and continuous improvement. Some factors still make reporting difficult, especially the low patient safety culture (CSP). Objective: Increase the quality level of the notification and learning process, based on the number and diversity of patient safety incidents in a regional public hospital. Methodology: The quality improvement project was carried out from January 2021 to June 2022, at Hospital Regional de Palmares. The study design was quasi-experimental, mixed type, comparable before and after and time series. The causes of the low number of safety incident reports were classified as an unmapped safety cause with the Ishikawa Diagram, where the low patient safety cause was classified. 13 interventions were chosen in a participatory and multifaceted way, covering: Leadership Development; Regulation and Standards; Organizational Capacity and Information Systems, grouped in the Affinity Diagram. To improve the improvement made with the learning of the change and learning process, all notifications being monthly. The context for improvement was drawn from the MUSIQ and CSP before and after the interventions. Results: MUSIQ scored 118, indicating that the project could be successful, but would face contextual barriers. The unfavorable context was also preserved by us at CSP. Even so, the number of patient safety incident reports showed a significant increase (p<0.05) in 6 of the 9 analysis criteria. The dimension of the frequency of reported CSP events showed an absolute improvement of 24% and a relative improvement of 47% (p=0.026). Of the 3 important survivals and developments, 11 were important, being the ones corresponding to the Organizational capacity of, the 111 main ones were the main ones. Conclusions: The intervention model implemented was useful to promote the increase of incident reports by professional patients and improve the learning in hospital safety patients with depth, its potential for reproduction in similar hospital characteristics.