Banca de DEFESA: HARETON TEIXEIRA VECHI

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : HARETON TEIXEIRA VECHI
DATE: 03/04/2024
TIME: 14:00
LOCAL: REMOTA - https://meet.google.com/waw-pqpi-bph
TITLE:

Factors associated with susceptibility to hepatitis A and B virus among men who have sex with men using HIV pre-exposure prophylaxis in Northeastern Brazil

KEY WORDS:

hepatitis A; hepatitis B; pre-exposure prophylaxis; men who have sex with men; vaccines

PAGES: 105
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Men who have sex with men (MSM) are disproportionately more affected by hepatitis A and B virus infections (HAV and HBV infections, respectively), and sexual practices have been implicated as important modes of transmission in this population. According to recommendations from the Ministry of Health, every individual on HIV pre-exposure prophylaxis (HIV PrEP), of which 80-90% are MSM, should undergo assessment of their immune status for HAV and HBV by serological tests to make clinical decisions, addressing individual and collective issues relating to the control and prevention of these infections. This study aims to evaluate the prevalence and factors associated with susceptibility to HAV and HBV among MSM on PrEP in Northeastern Brazil. It is a cross-sectional study conducted between September 2021 and June 2023, in which participants underwent structured interviews to collect sociodemographic and clinical information. Blood samples were also collected for screening for sexually transmitted infections (STIs) and serological testing for HAV and HBV. A total of 287 MSM were enrolled into the study. HAV susceptibility was found in 106 out of 282 (37.6%) participants. Factors associated with HAV susceptibility were: age < 30 years (prevalence ratio [PR]: 2.02; 95% confidence interval [95% CI]: 1.61-2.53), having health insurance (PR: 1.39; 95% CI: 1.19-1.64), sex only with cis men (PR: 1.52; 95% CI: 1.23-1.89), non-fixed sexual partner (PR: 1.20; 95% CI: 1.01-1.43), and no lifetime history of STIs (PR: 1.25; 95% CI: 1.03-1.53). HBV Susceptibility was found in 58 out of 286 (20.3%) individuals. HBV Susceptibility was significantly associated with: monthly income ≤ 5 minimum wages (RP: 2.02; 95% CI: 1.01 - 4.05), not having complete vaccination against hepatitis B (PR: 4.52; CI 95%: 2.89 - 7.06), initiation of PrEP (PR: 2.18; 95% CI: 1.21 - 3.94), six-month duration of PrEP (PR: 2.16; CI 95%: 1.19 - 3.91), absence of tattoos (PR: 1.55; 95% CI: 1.00 - 2.40), and absence of a medical history of STI (PR: 1.65; 95% CI: 1.07 - 2.54). A significant proportion of susceptibility to HAV and HBV is observed among MSM using PrEP in Northeastern Brazil. Socioeconomic factors, vaccination status, and sexual health issues play critical roles in determining this susceptibility. The integration of screening and vaccination for hepatitis A and B into PrEP services is essential to identify and address the susceptibility issue. Interventions that increase vaccination coverage and promote safer sexual practices are fundamental to mitigate the burden of these infections in this population

COMMITTEE MEMBERS:
Presidente - 277398 - KENIO COSTA DE LIMA
Externa ao Programa - 1645299 - MARISE REIS DE FREITAS - UFRNExterno à Instituição - LAURO VIEIRA PERDIGÃO NETO - USP