Banca de QUALIFICAÇÃO: ANA LUIZA CABRAL DE SÁ LEITÃO OLIVEIRA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : ANA LUIZA CABRAL DE SÁ LEITÃO OLIVEIRA
DATE: 01/03/2023
TIME: 09:00
LOCAL: UNIVERSIDADE DE LEIDEN - HOLANDA - ACORDO DE COTUTELA
TITLE:

MAXIMIZING THE POTENCY OF OXALIPLATIN COATED NANOPARTICLES WITH FOLIC ACID FOR MODULATING TUMOR PROGRESSION IN COLORECTAL CANCER

KEY WORDS:

Drug delivery system,Oxaliplatin,Folic acid,Apoptosis,Drug resistance

PAGES: 11
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

One of the challenges of nanotechnology is to improve the efficacy of treatments for diseases, in order to reduce morbidity and mortality rates. Following this line of study, we made a nanoparticle formulation with a small size, uniform surfaces, and a satisfactory encapsulation coefficient as a target for colorectal cancer cells. The results of binding and uptake prove that using the target system with folic acid works: Using this system, cytotoxicity and cell death are increased when compared to using free oxaliplatin. The data show that the system maximized the efficiency of oxaliplatin in modulating tumor progression, increasing apoptosis and decreasing resistance to the drug. Thus, for the first time, our findings suggest that PLGA-PEG-FA increases the antitumor effectiveness of oxaliplatin by functioning as a facilitator of drug delivery in colorectal cancer.

BANKING MEMBERS:
Externo ao Programa - 1958858 - LUIZ HENRIQUE DA SILVA GASPAROTTO
Presidente - 2329140 - RAIMUNDO FERNANDES DE ARAUJO JUNIOR