Banca de QUALIFICAÇÃO: José Flávio Vidal Coutinho
Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.STUDENT : José Flávio Vidal Coutinho
DATE: 05/10/2020
TIME: 08:00
LOCAL: DEFESA REMOTA - https://meet.google.com/wuv-jvrt-pcu
TITLE:
IMPACT OF THE USE OF COLLARS IMPREGNATED WITH DELTAMETHRIN ON THE SPATIAL DYNAMICS OF CANINE VISCERAL LEISHMANIASIS TRANSMISSION AND ON THE REDUCTION OF THE LUTZOMYIA LONGIPALPIS POPULATION.
KEY WORDS:
Canine visceral leishmaniasis, Leishmania infantum, collars impreganads with deltametrina, Lutzomyia longipalpis, spatial dynamics
PAGES: 52
BIG AREA: Ciências Biológicas
AREA: Bioquímica
SUMMARY:
Human and canine visceral leishmaniasis (VL) areas have increased in Brazil and other South American countries in the last 40 years, and new VL endemic areas usually first report outbreaks of canine disease followed by human disease. In this work, a prospective non-randomized study, with a 30-months follow up was conducted in Natal, Northeast Brazil, aiming to evaluate the effectiveness of 4% deltamethrin-impregnated collars in reducing the incidence Leishmania infantum infection in dogs. Serological surveillance for L. infantum infection was performed every 12-month and two collar replacements were performed. The spatial dynamics of canine Leishmania infection and sand fly fluctuation in the intervention area (collar use) and in the control area (no collar use) were determined. A total of 1249 and 1540 dogs were recruited at beginning of the study (t0), respectively, in the intervention and control areas, with canine serum infection rate by L. infantum of 9.6% and 19.8%. L. infantum transmission in the intervention area after 12 months was stable (Diff = -0.987; p = 0.931), however, it increased to 16.5% (Diff = -5.293; p = 0.024) after 15 months after last collar replacement. Among the dogs followed for the entire study period, there was a significant reduction in the incidence of L. infantum infection in the intervention area after 1 year (5.6% and 10.7%, p=0.0156). The total canine follow-up loss was 77.8% in the intervention area and 83.3% in the control area. In households from the intervention area, there was a decrease in the average number of Lutzomyia Longipalpis when compared houses with dogs versus without dogs (β1 = -2.5895; p=0.0171). Low canine population coverage, high rate of loss of follow-up and / or collars, high replacement of infected dogs collected by susceptible dogs are the main factors limiting the effectiveness of impregnated collars at community level.
BANKING MEMBERS:
Presidente - 350647 - SELMA MARIA BEZERRA JERONIMO
Externa ao Programa - 1549705 - ADRIANA FERREIRA UCHOA
Externa ao Programa - 1714243 - DANIELLA REGINA ARANTES MARTINS SALHA
Externa ao Programa - 3454276 - DENIZE ARAUJO BARBOSA