Banca de DEFESA: ANA GABRIELLA COSTA LEMOS DA SILVA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : ANA GABRIELLA COSTA LEMOS DA SILVA
DATE: 18/12/2023
TIME: 15:00
LOCAL: Plataforma Google Meet: https://meet.google.com/bcz-mtba-fti
TITLE:

Nutritional status of vitamin E and cardiovascular risk factors among adults and older adults: Brazuca Natal Study

KEY WORDS:

Vitamin E, Alpha-Tocopherol, Vitamin E deficiency, Cardiovascular risk factors, Food consumption.

PAGES: 131
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUBÁREA: Epidemiologia
SUMMARY:

Introduction: Cardiovascular diseases (CVD) are the principal cause of morbidity and mortality in the world. Therefore, experts have studied strategies for preventing and treating cardiovascular events. One of this knowledge is vitamin E stands out for its antioxidant and anti-inflammatory properties, supported by findings that higher dietary intake of vitamin E and higher concentrations of serum α-tocopherol (α-TOH) are associated with a lower risk of cardiovascular events. Therefore, data on the nutritional status of vitamin E in the population and its relationship with cardiovascular risk factors are relevant strategies to support programs and public policies aimed at preventing and treating CVD. Objective: To evaluate the nutritional status of vitamin E and its association with cardiovascular risk factors in adults and older adults in the Brazuca Natal Study. Methods: This is a study of different methodological strategies. 1) The narrative review aimed to verify if surveys could demonstrate an association between serum vitamin E and the occurrence of CVD. Moreover, we would like to understand whether vitamin E deficiency (VED) should also be considered a public health problem. 2) Cross-sectional study, divided into two scientific articles. The first article evaluated the prevalence of VED and whether cardiovascular risk factors influenced serum α-TOH status in adults and older adults in the Brazuca Natal Study. We performed a multiple linear regression analysis between serum α-TOH (dependent variable) and cardiovascular risk factors. The second article aimed to evaluate vitamin E intake, and we would like to identify the principal food sources of this micronutrient intake. To this end, we analyzed socioeconomic and demographic conditions (sex, age, color/race, education, per capita income, and health district of residence), and vitamin E intake (dependent variable). Results: In the narrative review, we observed that VED could be a public health problem. The prevalence of VED varies from 0.6% to 55.5% in the world, with higher percentages in Asia and Europe, where the high mortality rates from CVD stand out. Population studies suggest the protective effects of vitamin E on CVD. However, intervention studies with α-TOH supplementation have not confirmed its cardioprotective action. In article 2 of the cross-sectional study, we observed that 24.8% of adults and older adults in Natal had VED, and 89% had low concentrations of circulating α-TOH (below 30 µmol/L). We found that females had higher mean serum α-TOH values. In addition, the cardiovascular risk factors that increased the individuals' serum α-TOH were a high visceral adiposity index and higher global risk score values. Article 3 demonstrated that 95.7% of individuals had a low intake of vitamin E, considering the Estimated Average Requirement (EAR) of 12 mg/day, with lower intake values among older adults, women, and those who have a per capita income of less than half minimum wage and with less education. Soybean oil, açaí pulp, and red meat provided the highest content of ingested vitamin E. Conclusion: the study demonstrated a high prevalence of VED and low consumption of vitamin E in the studied population. We verified an association between serum α-TOH and cardiovascular risk factors.

COMMITTEE MEMBERS:
Presidente - 2149611 - CLELIA DE OLIVEIRA LYRA
Interno - 3926907 - DYEGO LEANDRO BEZERRA DE SOUZA
Interna - 2495705 - GRASIELA PIUVEZAM
Externo à Instituição - RICARDO NEY OLIVEIRA COBUCCI - UnP
Externo à Instituição - SORAIA PINHEIRO MACHADO ARRUDA - UECE