Banca de DEFESA: ANA CLARA DE FRANÇA NUNES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : ANA CLARA DE FRANÇA NUNES
DATA : 07/08/2019
HORA: 09:00
LOCAL: Departamento de saúde coletiva (DSC)
TÍTULO:

“Vitamin A and Symptoms of Multiple Sclerosis: A Systematic Review of Epidemiologic and Clinical Trial Studies”.

PALAVRAS-CHAVES:

Vitamin A, multiple sclerosis, nutritional supplements, inflammation, autoimmune diseases.

PÁGINAS: 54
GRANDE ÁREA: Ciências da Saúde
ÁREA: Saúde Coletiva
SUBÁREA: Epidemiologia
RESUMO:

Introduction: Multiple sclerosis (MS) is the most prevalent autoimmune disorder today and is associated with demyelination of neurons in the central nervous system (CNS) through activation of the immune system. Studies using vitamin A have been promising to improve the disease. Thus, the present dissertation aims to provide the best available evidence on the clinical impact of vitamin A on the outcomes related to symptoms of patients with MS. Methods: The article collection format was used for the production of two articles, the first one being a protocol article, used as the basis for the production of the second article, a systematic review. We searched the pubmed, embase, scopus, cinahl, scielo, web of science, cochrane library, and science direct for studies published until May 2019 to assess the relationship of vitamin A supplementation and / or serum level analysis and symptoms in patients with MS. For the design of the systematic review, PRISMA was used. To assess the methodological quality of the studies, the JADAD scale was used for randomized controlled trials and Newcastle – Ottawa for observational studies. To extract all the data found, a database was created in the Microsoft Excel program. Results: In the initial search we found 2053 studies, and at the end of the searches, 6 articles eligible for the research were selected, being 2 RCTs and 4 observational (cohort). Of the six studies included, two used vitamin A supplementation and obtained results that vitamin A is capable of containing upper limb progression and cognitive impairments, significant improvement in depression scores, total fatigue and the three fatigue subscales (physical, cognitive and psychosocial). The other four studies performed serum vitamin A dosing and found that serum retinol levels were not associated with risk and number of relapses and worsening of EDSS, but increasing retinol levels are associated with decreased results of disease activity. and retinol predict results of new lesions in subsequent months by magnetic resonance imaging. Conclusion: These findings are not yet sufficient to recommend vitamin A supplementation for MS patients. New well-controlled controlled trials are needed.

MEMBROS DA BANCA:
Presidente - 2495705 - GRASIELA PIUVEZAM
Externa ao Programa - 2549958 - LUCIA LEITE LAIS
Externa à Instituição - SANDRA MARIA NUNES MONTEIRO