Banca de DEFESA: DAVI NETO DE ARAÚJO SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : DAVI NETO DE ARAÚJO SILVA
DATA : 19/07/2018
HORA: 08:30
LOCAL: Departamento de Odontologia
TÍTULO:

Effects of antimicrobial photodynamic therapy with chloro-aluminum phthalocyanine on clinical parameters and salivary levels of GSH and MDA in patients with chronic periodontitis

PALAVRAS-CHAVES:

photochemotherapy, chronic periodontitis, subgingival scaling, supragingival scaling, treatment effectiveness, oxidative stress, malondialdehyde, glutathione.

PÁGINAS: 78
GRANDE ÁREA: Ciências da Saúde
ÁREA: Odontologia
SUBÁREA: Periodontia
RESUMO:

Antimicrobial photodynamic therapy (ADT) has been suggested as adjunctive therapy to basic periodontal scaling and coronal root straightening (RACR) therapy. In vitro and in vivo studies have demonstrated superior efficacy when PDA is performed with the photosensitizer chloro-aluminum phthalocyanine (AlClFc) in association with nanocarriers. Objective: To evaluate the efficacy of TFF with AlClFc in oral hygiene indexes, periodontal clinical parameters and salivary levels of oxidative stress markers (GHT) and malondialdehyde (MDA) in patients with chronic periodontitis. Methods: This randomized, double-blind, parallel, longitudinal, and prospective trial evaluated 22 patients in two groups: 14 in the test group (RACR + TFDA) and 8 in the control group (RACR only). Each patient had at least 2 diseased periodontal sites (PS≥5mm), totaling 63 periodontal sites, 40 sites belonging to patients in the test group, and 23 sites belonging to patients in the control group. The TFDA was applied once only after the completion of the RACR sessions. The oral hygiene indexes - visible plaque index [IPV], gingival bleeding index [ISG], and periodontal clinical parameters - probing bleeding [SS], probing depth [PS] and clinical insertion level [NIC] - were evaluated before treatment at T0, and after 3 months (T3) and 6 months (T6) times. Saliva samples were collected at each study time for GSH and MDA dosing. Data were statistically analyzed using non-parametric Wilcoxon and Mann-Whitney tests, with a significance level of 5% being pre-established. Results: The intragroup analysis showed that there was a statistically significant difference between the T0, T3 and T6 times with p <0.05 for the ISG, NIC and GSH variables only in the control group, but without detecting between the time pairs the difference. For PS, there was a significant decrease in the median in the test group between T0 (5.49) and T6 (4.33), with p1 = 0.008. In the control group there was also a significant difference between the three times, but it was not possible to identify among which there was this difference. For the other IPV, SS and MDA variables, there was no significant difference between the two groups. In the intergroup analysis, it was observed that there was a statistically significant reduction in the control group for the ISG in the T6 (p2 = 0.041) and the GSH in the test group in T3 (p2 = 0,031). For the other variables, there were no statistically significant differences between the two groups. Conclusion: TFAP with the adjuvant AlClFc photosensitizer to RACR did not bring additional benefits over periodontal clinical parameters after 6 months of treatment, but showed additional benefits over GSH after 03 months of treatment.

MEMBROS DA BANCA:
Presidente - 2085732 - ANA RAFAELA LUZ DE AQUINO MARTINS
Interno - 1752956 - EULER MACIEL DANTAS
Externo à Instituição - LUCIANA BASTOS ALVES - UFBA