Banca de QUALIFICAÇÃO: JOSEPH ANDREWS BELO ALVES

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : JOSEPH ANDREWS BELO ALVES
DATE: 28/03/2024
TIME: 14:00
LOCAL: https://meet.google.com/swt-tdhy-zdt
TITLE:

Synchronization of frontal brain networks by the respiratory rhythm in rats during exploration

KEY WORDS:

respiration; respiration coupled oscillations; behavior; active sensing; prefrontal cortex;

PAGES: 60
BIG AREA: Ciências Biológicas
AREA: Fisiologia
SUMMARY:

Yet essential, breathing means more to life than it looks. Besides cellular respiration, the rhythmic control of respiration has shown to be beneficial in cognition, increasing self-awareness and relaxation. However, it is unclear how the respiratory pattern changes relate to the brain and behavior. For instance, rodents synchronize sensorimotor rhythms to respiration during active sensing, such as head and whisker movements, suggesting that the breathing cycle could be relevant to the neural coding of the environment. Here, we examine rats' exploratory behavior to characterize how the breathing cycle associates with spontaneous actions. To that, we introduced animals in a gap paradigm where they could voluntarily interact with objects and social stimuli at different times while simultaneously recording the behavior, respiration, and frontal brain electrical activity of rats during spontaneous performance. We segmented the observable behavior and extracted measures of locomotion and head movements from quiet, object, and social investigation. Our results show that rodents displayed both immobility and exploratory behavior distinctly, depending on the stimulus, being more engaged in social interaction compared to object investigation. We also identified higher respiratory rates when the animal was over the gap in both contexts. We’ve observed respiration-coupled oscillations in the olfactory bulb and frontal cortex areas, with higher amplitudes than reported in previous studies (~ 8-10 Hz). We conclude that the respiration cycle is relevant to rat exploratory behavior and that the respiration-coupled oscillations could mediate the interplay between respiration, behavior, and cognition, being an approach to studying the mechanisms behind the behavioral modulation by the respiratory cycle.

COMMITTEE MEMBERS:
Interno - 1721223 - ADRIANO BRETANHA LOPES TORT
Presidente - 2069422 - DIEGO ANDRES LAPLAGNE
Interna - 1871878 - KERSTIN ERIKA SCHMIDT