Banca de QUALIFICAÇÃO: DAVI DRIESKENS CARVALHO DE CASTRO SÁ BARRETO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : DAVI DRIESKENS CARVALHO DE CASTRO SÁ BARRETO
DATE: 29/10/2021
TIME: 15:00
LOCAL: https://meet.google.com/cph-fhgm-ohx
TITLE:

Gating of respiratory-coupled frontal cortex activity across behavioral and cognitive states in the freely-behaving rat

KEY WORDS:

mpfc; respiration, oscillations, theta, gamma, delta, rat

PAGES: 50
BIG AREA: Ciências Biológicas
AREA: Fisiologia
SUMMARY:

In 1942, work by Edgar Adrian showed that the rhythmic flux of air in the olfactory epithelium of hedgehogs generates oscillations in the olfactory bulb. Recent work in rodents has shown that neuronal oscillations synchronized to the phase of the respiratory cycle occur not only at the olfactory bulb but also across distant brain areas, from prefrontal to visual cortices to subcortical areas, such as the hippocampus and the amygdala. Intriguingly, these widespread respiratory brain rhythms are not continuously present. Instead, the coupling between neuronal activity and respiration across brain regions changes dramatically with time. Previous work also showed that the power of these respiration entrained oscillations is higher in frontal areas. 

To understand these dynamics, we simultaneously recorded depth video along with respiration (intranasal pressure) and distributed brain signals (anterior cingulate, prelimbic, medial orbital  and parietal cortices and olfactory bulb) in 6 rats as they freely behaved in an open field arena with objects (21 sessions of 30 minutes each). 

Animals displayed a rich set of behavior, ranging from immobility (quiet awake/sleep) to walking, grooming, rearing and object exploration. In this presentation, we will present and discuss results on the coupling of low and high-frequency components of the local field potential (LFP) to the respiratory rhythm. We will show how the magnitude of this coupling is strongly dependent on the instantaneous respiratory rate of the rats and recording site. To better dissect possible modulations of coupling strength, we detected and selected the behavioral state of the animals and quantified the LFP-respiration coupling for each one. We will show how the gating of respiratory signals depends on the ongoing behavioral/cognitive state of the rat.

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