Banca de DEFESA: MARINA PÁDUA REIS

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : MARINA PÁDUA REIS
DATA : 14/03/2019
HORA: 14:00
LOCAL: INSTITUTO DO CEREBRO
TÍTULO:

On the role of the perirhinal cortex in object recognition memory reconsolidation

PALAVRAS-CHAVES:

memory, reconsolidation, object recognition, peririnal cortex

 

 

PÁGINAS: 57
GRANDE ÁREA: Ciências Biológicas
ÁREA: Fisiologia
RESUMO:

Consolidated memories can become labile when reactivated and, to persist, must undergo a protein synthesis-dependent restabilization process called reconsolidation. The perirhinal cortex (PER) regulates the flow of information between different brain areas and although it has been implicated in object recognition memory (ORM) reconsolidation, the actual role of PER in this process remains controversial. Using the novel object recognition task we investigated the conditions that constrain PER involvement in ORM reconsolidation. We found that bilateral intra-PER infusions of the protein synthesis inhibitor anisomycin caused amnesia when administered immediately after ORM reactivation in the presence of a familiar object but not when memory was reactivated in the presence of a new object, two familiar objects, or a new object alongside a familiar one. Immunofluorescence analyses revealed a prominent increase in PER ZIF268 expression only after ORM reactivation in the presence of a single familiar object. We also found that PER NMDAr blockade with the selective NMDAr antagonist AP5 and ZIF268 expression knockdown with antisense oligonucleotides hindered ORM reconsolidation. Our results indicate that partial perception of recognition cues during memory reactivation is a boundary condition for the participation of PER in ORM reconsolidation, and suggest that this process involves NMDAr activation and ZIF268 expression in that cortex.

MEMBROS DA BANCA:
Presidente - 1996111 - MARTIN PABLO CAMMAROTA
Interno - 2069422 - DIEGO ANDRES LAPLAGNE
Externa ao Programa - 1644341 - ANA CAROLINA LUCHIARI
Externa à Instituição - CYNTHIA LORENA KATCHE - UBA
Externo à Instituição - FLAVIO FREITAS BARBOSA - UFPB