Banca de QUALIFICAÇÃO: RUANN RAMIRES NUNES PAIVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : RUANN RAMIRES NUNES PAIVA
DATE: 15/12/2023
TIME: 14:00
LOCAL: Sala de Reunião, CB, UFRN
TITLE:

GENETIC POLYMORPHISM AS A BIOMONITORING STRATEGY: APPLICATION IN THE STUDY OF RADON IN THE SEMI-ARID POTIGUAR IN THE CONTEXT OF EXPOSURE TO RADON

KEY WORDS:

Radon, Cancer, Polymorphism, GSTT1, GSTM1.

PAGES: 63
BIG AREA: Outra
AREA: Ciências Ambientais
SUMMARY:

Natural ionizing radiation is a global concern because it is present in the environment and can impact the health of individuals. One of the natural sources of ionizing radiation is Radon, a colorless, odorless and tasteless gas that releases alpha particles, constituting a source of concern when inhaled, since the release of alpha particles causes damage to biomolecules, contributing to the development of cancers, mainly when individuals are chronically exposed to this element. Therefore, a more detailed analysis of the damage caused by alpha radiation in biomolecules and the molecular mechanisms that individuals have to deal with this natural element is necessary. One of these mechanisms is the gene family of Glutathione S-transferases, enzymes that detoxify xenobiotics in phase II of the biotransformation process and have their null polymorphism associated with susceptibility to several clinical cases of cancer, especially the nullity of the GSTT1 and GSTM1 genes. Thus, in addition to a theoretical understanding of the genes presented, the study carried out an evaluation of the polymorphism of the GSTT1 and GSTM1 genes in a population chronically exposed to high doses of radon, evaluating not only the polymorphism of the genes, but also an association between demographic factors and style of life. The work also presents a report of extension activities developed in the municipality of Lajes Pintadas-RN, a study area chosen and justified through data present in the scientific literature, in order to contribute to local development by providing the community with technical information about the effects of natural ionizing radioactivity on chronically exposed individuals, which can support public health policies in order to help achieve the Sustainable Development Goals (SDGs) proposed by the United Nations (UN).

COMMITTEE MEMBERS:
Presidente - 1674709 - VIVIANE SOUZA DO AMARAL
Interna - 1121066 - ELIZA MARIA XAVIER FREIRE
Externa à Instituição - MARIALVA SINIGAGLIA - UFRGS