Banca de DEFESA: EDNA KARLA FERREIRA LAURENTINO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : EDNA KARLA FERREIRA LAURENTINO
DATE: 04/03/2024
TIME: 14:30
LOCAL: sala 05 do departamento de Fisioterapia da UFRN
TITLE:

ACUTE EFFECTS OF THE ACTION OF CANNABIS OIL IN FULL SPECTRUM EXTRACTION AND ISOLATED THC ON RESPIRATORY MECHANICS, MUSCLE ELECTRICAL ACTIVITY AND PERIPHERAL CARDIOVASCULAR HEMODIN MIC IN HEALTHY INDIVIDUALS

KEY WORDS:

Cannabis; Cannabinol; Tetrahydrocannabinol; Electromyography; Respiratory Mechanics.

PAGES: 50
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

Abstract: The effects of CBD and THC on the human body are due to the endocannabinoid system, which includes cannabinoid receptors type 1 (CB1) and type 2 (CB2), present in several types of cells throughout the body, including in the cardiovascular system, lungs and pulmonary vessels in animals and humans, however, little is known about the action on respiratory mechanics. Given the above, the objective of this study is to analyze the action of cannabis oil in removing full spectrum and THC on respiratory mechanics, muscular electrical activity and cardiovascular hemodynamics. This is a randomized, controlled, crossover, double-blind clinical trial. Therefore, individuals were allocated to a single group that participated in three phases with distinct interventions: Intervention-Full Spectrum (I-fs), Intervention-THC (I-THC) and Placebo Intervention (IP). The sample size and dosage used were defined based on pharmacological information available in the literature and finally confirmed in a pilot study with 10 subjects. The study included young men and women between 18 and 50 years old, who declared themselves healthy, with a body mass index (BMI) within the normal range, who did not present changes in respiratory function (confirmed in previous spirometry), did not present psychological or uncontrolled/treated psychiatric patients, do not use regular medications or have been exposed to cannabis in the last 6 months prior to the first day of assessment. The collection is carried out over three assessment days, and the team consists of a researcher responsible for randomization, and three others responsible for the baseline assessment with strength and lung function tests (spirometry), drug administration and evaluation of the intervention, which occurs in three stages: 1-Pre Intervention (Pre-IN); 2-Intervention (IN) and 3-Post-Intervention (Post-IN). All participants in the three assessment stages consist of: Assessment of respiratory mechanics using a Pneumotachograph, Electromyography of the Sternocleidomastoid, Scalenes, Parasternal and Rectus Abdominis muscles, and Assessment of cardiovascular hemodynamics (PhysioFlow) where 8 minutes will be recorded, with 2 minutes in Quiet breathing, 2 minutes of breathing with an inspiratory resistance of 30% of your MIP and an expiratory resistance of 10% of your MEP, and another 4 minutes of recovery in each stage for later analysis, in addition to the presence and severity of anxiety symptoms in the participant through Hamilton Anxiety Scale (HAM-A). The results of this research, carried out with 09 subjects, 04 women and 05 men, aged 24 ± 3.29 years, BMI 23.12 ± 2.11 kg/m2, declared an expected increase in ECOM muscular electrical activity, ESC, PARA and RA at the time of load pressure limits of 30% of the MIP and 10% of the MEP of the participants compared to the moment in Quiet breathing, with a difference between this increase in relation to the substances used, observing ΔQB/valve of ECOM of Δ=22.22 (placebo), Δ=17.94 (full spectrum) and Δ=23.04 (thc), ESC of Δ=11.33 (placebo), Δ=10.56 (full - spectrum) and Δ=16.25 (thc), TO of Δ=15.29 (placebo), Δ=10.67 (full spectrum) and Δ=17.05 (thc), and RA of Δ=1.34 (placebo), Δ=0.15 (full spectrum) and Δ=0.95 (thc). Despite the widespread use of full spectrum cannabis oil, safety studies regarding its administration are scarce, with a phase 1 study seeking to establish the effects of the substance on the respiratory and cardiovascular system as the first analysis for the safety of its use and enhancing rehabilitation techniques in respiratory and cardiovascular physiotherapy.

COMMITTEE MEMBERS:
Presidente - 1545315 - GUILHERME AUGUSTO DE FREITAS FREGONEZI
Externa ao Programa - 3358154 - GIANE AMORIM RIBEIRO SAMORA - UFRNExterna à Instituição - JESSICA DANIELLE MEDEIROS DA FONSECA