Banca de DEFESA: BRUNA RIBEIRO CARNEIRO DE SOUSA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : BRUNA RIBEIRO CARNEIRO DE SOUSA
DATE: 29/02/2024
TIME: 14:30
LOCAL: Hibrido
TITLE:

EFFECTS OF HIGH-DEFINITION TRANSCRANIAL DIRECT CURRENT STIMULATION (HD-TDCS) ON UPPER LIMB MUSCLE ACTIVITY IN PEOPLE WITH IT: PROTOCOL FOR A DOUBLE-BLIND PARALLEL RANDOMIZED CLINICAL TRIAL AND CASE SERIES.

KEY WORDS:

Amyotrophic lateral sclerosis; IN G; TDCS; Wearable Electronic Devices.

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

INTRODUCTION: Amyotrophic Lateral Sclerosis (ALS) is an acquired, neurodegenerative and disabling disease of the nervous system, causing motor and extra-motor symptoms. It is described by a functional decline in affected people. In ALS, studies related to tDCS present consolidated results on the hypotheses of hyperexcitability in the corticomotor neural system, with some interesting aspects in its mechanisms of action that could minimize this hyperexcitability. According to the assembly in target areas, tDCS' main action is to act on the resting membrane potential and produce a prolonged suppression of neuronal excitability. This effect is determined by the modulation of dependent synaptic plasticity, which induces a return of the cell to its physiological conditions. The main objective of this study is to evaluate the effects of a HighDefinition Transcranial Direct Current Stimulation (HD-tDCS) protocol on the motor performance of the upper limbs of people with ALS.METHODOLOGY: This is a randomized controlled, parallel, double-blind clinical trial protocol with 2 arms, 1:1 allocation, following the recommendations of the Consolidated Standards of Reporting Trials (CONSORT), based on the Standard Protocol Items Recommendations for Interventional Trials (SPIRIT). Subjects will be included if they have been diagnosed with ALS according to the revised El Escorial criteria, are aged between 18 and 80, have a good cognitive level on the ALS Cgntv Bhvrl Srn sl (≥17 pnts), nd r able to understand and perform simple motor actions based on verbal commands. Participants will be recruited from the Neuromuscular Diseases Outpatient Clinic at the Onofre Lopes University Hospital (HUOL) and assessed before the intervention (PRE), one week after the intervention (POS1) and 2 weeks after the intervention (POS2). The experimental group will undergo an initial assessment, and if they meet the inclusion criteria, they will undergo five sessions of HD-TDCS on consecutive days (one session each day), which will last 20 minutes and have an intensity of 3mA. The Sham group will receive simulations of the application of high-definition tDCS, with the device providing an acceleration period of 30 s up to the full 3 mA, followed immediately by a 30 s reduction. In addition to describing the protocol, this study describes a case report of a participant diagnosed with ALS since September 2022 who underwent the HD-tDCS intervention protocol described. Results: It was found that in a functional activity protocol, most of the characteristics of the analyzed muscle activation signals were higher in POS1 and POS2 compared to PRE. Discussion: Changes were found in the electromyographic signals after the intervention was applied, which indicates that the protocol is viable; however, the clinical trial described above is necessary to validate the protocol's efficacy and safety.

COMMITTEE MEMBERS:
Presidente - 2179208 - ANA RAQUEL RODRIGUES LINDQUIST
Interna - 2374822 - FABRICIA AZEVEDO DA COSTA CAVALCANTI
Externa à Instituição - LUCIANA PROTASIO DE MELO