Banca de QUALIFICAÇÃO: EDNA KARLA FERREIRA LAURENTINO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : EDNA KARLA FERREIRA LAURENTINO
DATE: 08/12/2023
TIME: 14:00
LOCAL: Departamento de Fisioterapia
TITLE:

ACUTE EFFECTS OF FULL SPECTRUM CANNABIS OIL AND ISOLATED THC ON MUSCLE ELECTRICAL ACTIVITY IN HEALTHY INDIVIDUALS: OBSERVATIONAL STUDY.

KEY WORDS:

Cannabis; Cannabinol; Tetrahydrocannabinol; Electromyography; Respiratory Mechanics

PAGES: 41
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

ABSTRACT: O canabidiol (CBD) and Tetrahydrocannabinol (THC) are endocannabinoid compounds extracted from the cannabis sativa plant that have beneficial effects on psychological and systemic disorders, such as schizophrenia, diabetes, cardiovascular diseases, and cancer. New outcomes for their medicinal use are emerging every day. The effects of CBD and THC on the human body are due to the endocannabinoid system, which includes cannabinoid receptors type 1 (CB1) and type 2 (CB2), present in various types of cells throughout the body, including the cardiovascular system, lungs, and pulmonary vessels in both animals and humans. However, little is known about their action on respiratory mechanics and hemodynamics. In light of the above, the objective of this observational, descriptive study is to analyze the action of full-spectrum cannabis oil and isolated THC on respiratory mechanics and inspiratory muscle electrical activity. This is a secondary observational study, part of a crossover, randomized controlled, and double-blind clinical trial. Individuals were allocated to a single group that participated in three phases with different interventions: Full Spectrum Intervention Phase (FI-fs), THC Intervention Phase (FI-THC), and Placebo Phase (FP). The sample size and dosage used were defined based on pharmacological information available in the literature and finally confirmed in a pilot study with 10 subjects, and its analysis will use GPower software version 3.1.94 (Kiel, Germany) for Windows. The study included young men and women aged between 18 and 50 years who self-declared as healthy, with a normal body mass index, no alterations in respiratory function, no untreated/ uncontrolled psychological disorders, no regular medication use, and no exposure to cannabis in the last 6 months. Data collection took place over three evaluation days, with a research team consisting of one researcher responsible for randomization and three others responsible for drug administration and evaluation, occurring in three stages: 1-Pre-Intervention (PREin); 2-Intervention (IN); and 3-Post-Intervention (POST-in). All subjects participated in the three evaluation stages, which included strength testing (PImax and PEmax), pulmonary function testing (spirometry), evaluation of variations in chest wall volumes and respiratory mechanics using Optoelectronic Plethysmography, Electromyography, and hemodynamic evaluation by electrical impedance using Physioflow. Six minutes were recorded, with 2 minutes of spontaneous breathing, 2 minutes of breathing with 30% inspiratory resistance of their PImax, and an additional 2 minutes of recovery in each stage for later analysis. The results of this research will only consider the observational evaluation of muscle electrical activity through electromyography in the PRE-in, IN, and POST-in phases.

COMMITTEE MEMBERS:
Presidente - 1545315 - GUILHERME AUGUSTO DE FREITAS FREGONEZI
Externa ao Programa - 3358154 - GIANE AMORIM RIBEIRO SAMORA - UFRNExterna à Instituição - JESSICA DANIELLE MEDEIROS DA FONSECA