Banca de QUALIFICAÇÃO: THIAGO BEZERRA WANDERLEY E LIMA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : THIAGO BEZERRA WANDERLEY E LIMA
DATE: 15/12/2023
TIME: 15:00
LOCAL: Auditório do prédio de fisioterapia
TITLE:

METHODS OF NORMALIZATION AND ANALYSIS OF RESPIRATORY  MUSCLE FATIGUE IN PATIENTS WITH AMIOTROPHIC LATERAL SCLEROSIS AND HEALTHY SUBJECTS

KEY WORDS:

Surface electromyography; muscle fatigue; respiratory muscles

PAGES: 38
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

Introduction: Surface electromyography (sEMG) is one of the methods used to
assess the muscle electrical activity of an individual, whether during rest or
any activity. EMG can be used to evaluate skeletal and respiratory muscles in
both healthy individuals and those with pathologies, allowing for an analysis
across different days, individuals, and situations. Amyotrophic lateral sclerosis
(ALS) is a progressive neurodegenerative disease characterized by
generalized muscle weakness. One of the main causes of death in these
patients is due to respiratory muscle weakness and consequent ventilatory
failure. EMG becomes an important tool for monitoring respiratory muscles in
ALS patients, enabling an understanding of muscle recruitment patterns and
potential muscle dysfunctions in these individuals. The electromyographic
signal may be influenced by intrinsic and extrinsic factors. Therefore, it is
important to seek methods aimed at minimizing the interference of these
factors, making the results as reliable as possible. One of the alternatives
used for this process is normalization. There is still no consensus in the
literature on the best way to perform normalization. Objective 1: Compare
different normalization methods of the EMG signal from respiratory muscles in
ALS patients and healthy subjects. Objective 2: Evaluate and compare
inspiratory muscle fatigue during the nasal inspiratory pressure maneuver
(SNIP) between ALS patients and healthy individuals. Methods: This is a
cross-sectional study, approved by the University Ethics Committee under
opinion number 424,987/2013, with 67 participants, including 50 healthy
subjects and 17 ALS patients. The electrical activity of the
sternocleidomastoid (SCM), scalene (SCA), diaphragm (DIA), parasternal
(PS), external intercostal (EI), external oblique (EO), and rectus abdominis 

(RA) muscles was analyzed during maximum inspiratory pressure (MIP), nasal
inspiratory pressure (SNIP), maximum expiratory pressure (MEP), and
maximum voluntary isometric contraction of SCM and SCA (MVIC-SCM/SCA)
and RA (MVIC-RA). EMG comparisons were made considering the division of
maneuvers and muscles into inspiratory and expiratory. Additionally, variables
for fatigue analysis, such as median frequency (MF), high frequency (H), low
frequency (L), and high/low frequency ratio (H/L), were extracted during the
SNIP maneuver. Results: The present thesis is presented in 2 articles: Article
1: Methods to normalize surface electromyography in respiratory muscles: is it
similar between ALS and healthy people?; Article 2: Analysis of inspiratory
muscle fatigue through surface electromyography during the nasal inspiratory
pressure maneuver (SNIP) in healthy subjects and those with amyotrophic
lateral sclerosis (ALS). Conclusion: The normalization method using MVIC
was the one in which respiratory muscles showed higher electrical muscle
activity for both inspiratory and expiratory maneuvers. Furthermore, there is no
difference in the SNIP maneuver regarding frequency variables for fatigue
development analysis between ALS and healthy subjects.

COMMITTEE MEMBERS:
Presidente - 1545315 - GUILHERME AUGUSTO DE FREITAS FREGONEZI
Externa ao Programa - 3358154 - GIANE AMORIM RIBEIRO SAMORA - UFRNExterna à Instituição - JESSICA DANIELLE MEDEIROS DA FONSECA