Banca de DEFESA: ELIZANE POQUIVIQUI DO NASCIMENTO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ELIZANE POQUIVIQUI DO NASCIMENTO
DATE: 27/05/2022
TIME: 14:00
LOCAL: VIDEOCONFERÊNCIA
TITLE:

PHYSICAL CAPACITY AND TISSUE OXYGENATION IN POST-COVID-19 PATIENTS

KEY WORDS:

Exercise Tolerance; Coronavirus Infections;
Spectroscopy, Near-Infrared

PAGES: 40
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

Scientific and clinical evidence points to a persistent impairment of functional capacity in post-COVID-19 individuals, however the cause of functional limitation and symptomatology still need to be elucidated. Thus, the objective of this study was to evaluate and compare functional capacity in post-Covid-19 patients versus a control group, in addition to analyzing cardiac hemodynamics and tissue muscle oxygenation response during the assessment protocols in both groups. This is a cross-sectional study in patients diagnosed with COVID-19 who were hospitalized or not, older than 18 years of both sexes compared to a control group. We used two functional tests for performance analysis and comparison: the 6-minute walk test (6MWT) and the 1-min sit-and-stand test (1-STS). In addition to the performance variables, heart rate, peripheral O2 saturation and symptoms (dyspnea and fatigue), we evaluated the cardiac hemodynamic response by impedance (systolic volume, stroke volume index (SVi), cardiac output, cardiac index (CI), Systemic Vascular Resistance (SVR), Systemic Vascular Resistance Index, Ejection Fraction (EF), End Diastolic Volume, Ventricular Filling Time and Contractility Index (TCI)) during the 1-STS protocol. Tissue perfusion responses to vastus lateralis muscle oxygenation (oxyhemoglobin (O2Hb), deoxyhemoglobin (HHb), total hemoglobin (tHb) and tissue saturation index (TSI)) were recorded before, during and after two minutes (recovery) in both tests. For data analysis, we used the statistical program GraphPad Prism 8.0 with significance levels p<0.05 and a confidence interval of 95% and for the intragroup comparisons of the variables, we performed the Friedman test while in the Mann-Whitney intergroup comparisons. Thirty-six patients were included in the study, 13 (36.11%) women and 23 (63.88%) men, with a median age of 36.00 (29.00-51.00) years old and with a BMI of 26. 51(24.06-30.32) in the post-COVID-19 group and 11 individuals in the control group, 8 (72.72%) women and 3 (27.27%) men, with a median age of 25.00(23) .00-39.00) years and with a BMI of 23.71(22.54-28.28). When comparing the groups, the post-COVID-19 group showed a 20% reduction in performance versus control in the distance covered in the 6MWT (p=0.0001) and of 28% in the number of repetitions of the 1-STS (p=0.01 ). Furthermore, there were intergroup differences in cardiac hemodynamics variables during the 1-STS protocol, where the post-COVID-19 group showed a reduction of 18% in VSi (p=0.004), of 21% in CI (p=0.0009), of 78% in ICT (p=0.0001) and 29% in EF (p=0.0003) and an increase in SVR by 25% (p=0.03) and 27% in RVSi (p=0, 0007). Despite the lower functional performance, the tissue oxygenation variables during the 6MWT and 1-STS tests and in the recovery phase showed responses of similar magnitude between people with COVID-19 and healthy controls, with no statistically significant intergroup difference in the variables studied. Thus, our results suggest that the post-COVID-19 group, when compared to uninfected subjects, present (I) a reduction in functional capacity identified by both tests, by 28% in the 1-STS and 20% in the 6MWT, (II) changes in the Cardiac hemodynamic responses and systemic vascular resistance (III) similar pattern of muscle oxygen supply and consumption in both tests similar in both groups. We suggest that a study with a larger sample size and stratification of groups post COVID-19 to complement these findings.

BANKING MEMBERS:
Presidente - 5566309 - VANESSA REGIANE RESQUETI FREGONEZI
Externo ao Programa - 3296783 - SAINT CLAIR GOMES BERNARDES NETO
Externo à Instituição - RENCIO BENTO FLORENCIO - UNICEUNA