Banca de QUALIFICAÇÃO: ELIZANE POQUIVIQUI DO NASCIMENTO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ELIZANE POQUIVIQUI DO NASCIMENTO
DATE: 20/07/2021
TIME: 14:30
LOCAL: Vídeo Conferência
TITLE:

Analysis of physical capacity and tissue oxygenation in patients after COVID-19

KEY WORDS:

Exercise Tolerance; COVID-19

PAGES: 40
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

Scientific and clinical evidence points a persistent impairment of physical capacity in post-COVID-19 individuals. Such residual effects can persist for months and can be influenced by the severity of the infection and the need for hospitalization and the use of ventilatory support. Aim: To evaluate physical capacity and analyze the behavior of tissue muscle oxygenation during exercise capacity tests in patients after COVID-19. Methodology: This is a cross-sectional study in patients diagnosed with COVID-19 who have or have not been hospitalized, over 18 years of age, of both sexes. All subjects were divided into 3 groups according to the severity of the cases: Individuals who required admission to the ICU: Intensive care group (COVID-ICU), Individuals who required admission only on the infirmary: Group Infirmary (COVID-I) and individuals who did not need hospitalization: Group Not hospitalized (COVID-NH). After anamnesis, two physical capacity tests were performed, the six-minute walk test (6MWT) and the 1-minute sit to stand test (1-STS). For symptoms of dyspnea and fatigue, we used the Borg scale of 0-10. Both tests were performed with the concomitant analysis of tissue oxygenation of the vastus-lateral muscle by near infrared spectroscopy (NIRS- (Portamon Artinis Medical Systems, BV, Netherland) The values of oxyhemoglobin (O2Hb), deoxyhemoglobin (HHb), hemoglobin total (tHb- that expresses the concentration of hemoglobin and measurement of total blood volume at the site being an indirect measure of total blood flow in the tissue) and the difference between oxyhemoglobin and deoxyhemoglobin (HbDiff) were assessed at baseline, during and immediately after the completion of the tests. We used mean and standard deviation for normal distribution and intragroup comparisons of variables were performed using Friedman, while intergroup comparisons were performed by Kruskal-Wallis. Data were analyzed using the statistical program GraphPad Prism 8.0 (GraphPad Software Inc SanDiego California, USA) with significance levels p <0.05 and 95% Confidence Interval. Results: So far 30 volunteers have been included, 7 in the COVID-ICU group (age: 37.86 ± 15.49 years), 8 in the COVID-I group (age: 47.63 ± 10.69 years) and 15 in the COVID-NH group (age: 35.80 ± 11.83 years). In relation to the 6MWT, the intergroup analysis showed that the COVID-ICU group and COVID-I group had shorter distances when compared to the COVID-NH group (COVID-ICU 505 m, 84% pred; COVID-E 475m, 84% pred and COVID-NH 564m, 95% pred, (p = 0.01 and p = 0.02), respectively. In the 1-STS we identified a reduction in physical capacity in all groups (COVID-ICU 38rep, 81% pred; COVID- And 32rep, 76% pred and COVID-NI 34rep, 71% pred), but with no intergroup statistical difference, both tests found high values of dyspnea and fatigue at the final moment, however without intergroup differences. Regarding peripheral tissue oxygenation, it was observed in the 6MWT that the COVID-NH group had a lower drop in HbDiff and O2HB during the test when compared to the COVID-ICU and COVID-I groups and greater variation in tHb when compared to the previous ones. There was also a small variation in HHb in the three groups, but in the COVID-ICU there was a smaller decrease compared to the other two, with no statistical difference. In the 1-STS, the three groups had a similar drop in HbDiff during the test, however, the COVID-ICU group showed a greater increase in this variable after the test. It was not possible to observe a difference in the behavior of the variation between the groups regarding the variable tHb during the test or even at the time of recovery. Thus, as preliminary results, we can suggest that the 6MWT and 1-STS tests were able to identify a decline in physical capacity in post-COVID-19 patients, with 6MWT being able to differentiate patients who need hospitalization (ICU or Infirmary) of those not hospitalized. Furthermore, the behavior in tissue oxygenation during the tests seems to be influenced by the severity level of COVID-19.

BANKING MEMBERS:
Presidente - 5566309 - VANESSA REGIANE RESQUETI FREGONEZI
Externa ao Programa - 2646588 - JOCELINE CASSIA FEREZINI DE SA
Externo ao Programa - 4246118 - RENCIO BENTO FLORENCIO