Banca de QUALIFICAÇÃO: KAREN DE MEDEIROS PONDOFE

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : KAREN DE MEDEIROS PONDOFE
DATE: 05/03/2021
TIME: 09:00
LOCAL: Vídeo Conferência
TITLE:

Impact of an optimised approach to home-based respiratory care in individuals with Amyotrophic Lateral Sclerosis: a study protocol for a randomised controlled trial

KEY WORDS:

Amyotrophic lateral sclerosis, Lung capacity, Chest wall volumes, Cough, Respiratory care

PAGES: 24
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

This study aims to investigate the effects of an optimal home-based respiratory care protocol in individuals with ALS. Methods and analysis This is a randomised, blinded controlled trial involving subjects diagnosed with ALS. Subjects will be randomly allocated into two groups: the conventional respiratory care group (CRC) and the optimised respiratory care home-based group (ORC). Primary outcomes will be peak cough flow, number of exacerbations and ALS Functional Rating Scale Revised. Secondary outcomes will include chest wall volumes, maximal respiratory pressures, sniff nasal inspiratory pressure, nasal expiratory pressure and forced vital capacity (FVC), forced expiratory volume in the 1st second (FEV₁), and FEV₁/FVC. The CRC group will receive educational information of respiratory care at the clinic. The ORC group will receive conventional care and home-based care. The clinical status of all individuals will be monitored weekly through telephone calls. A 6-month intervention is planned, the outcomes will be assessed every three months, and a 12-month follow-up after intervention. The primary and secondary results will be described as average or median for continuous variables and absolute and relative frequencies for qualitative variables. Treatment effects or differences between the outcomes (baseline, three months, and six months) of the study groups will be analysed using an ANOVA. The level of significance will be set as p≤0.05. Ethics and dissemination The research ethics committee approved the study. It is expected to evaluate respiratory function in patients with ALS in the short, medium, and long terms to demonstrate the best strategy for increasing the patient’s quality of life with home-based care protocol. The rapid progression of the disease is a limitation for performing a long-term clinical study. Registration details Clinical Trial Registry: Brazilian Clinical Trial Registry, No. RBR-3z23ts on August 7, 2019.

BANKING MEMBERS:
Externa ao Programa - 2211046 - LUCIEN PERONI GUALDI
Interna - 2319151 - TATIANA SOUZA RIBEIRO
Presidente - 5566309 - VANESSA REGIANE RESQUETI FREGONEZI