Banca de DEFESA: ISAURA RUTH VIEIRA DA COSTA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ISAURA RUTH VIEIRA DA COSTA
DATE: 11/04/2024
TIME: 14:00
LOCAL: Google meet
TITLE:

FEEDING TIME MATTERS? INFLUENCE OF TIME-RESTRICTED FEEDING ON MOTOR AND COGNITIVE ASPECTS IN A CHRONIC MODEL OF PARKINSON'S DISEASE IN RATS

KEY WORDS:

reserpine, time-restricted feeding, parkinson’s disease.

PAGES: 70
BIG AREA: Ciências Humanas
AREA: Psicologia
SUMMARY:

Parkinson's disease (PD) stands as the second most prevalent global neurodegenerative condition, affecting over 10 million individuals worldwide, with heterogeneous clinical manifestations. Animal models such as reserpine are widely used to evaluate their physiological mechanisms and possible therapeutic interventions. Time-restricted feeding (TRF), defined as the temporal adjustment of food availability without caloric restriction emerges as a potential complementary treatment in neurodegenerative disorders. Here, we evaluated the motor and cognitive effects of a time-restricted feeding intervention in a rat model of Parkinson’s disease induced by reserpine. Male Wistar rats (3-4 months) were randomly assigned to three treatment groups: time-restricted feeding for 60 days, starting 30 days before reserpine injections; time-restricted feeding for 30 days, starting with reserpine injections; and ad libitum food with reserpine injections; and two control groups: time-restricted feeding for 30 days, starting with vehicle injections and ad libitum food with vehicle injections. All animals were submitted the following tests: catalepsy test, oral movements, open field (OFT) and novel object recognition (NOR). All reserpine groups showed a progressive motor deficit, as observed in the catalepsy and vacuous chewing tests, but the TRF groups showed a delay in the onset of motor symptoms in comparison with their respective ad libitum group. Differences in performances on NOR test or OFT were not found between the reserpine groups after the intervention. Here we showed the promising effects of a time-restricted feeding diet on motor symptoms, but not cognitive symptoms caused by chronic exposure to reserpine. This is the first study to investigate TRF in a chronic model of Parkinson’s disease. Further research is needed to explore the different effects of TRF on emotional and cognitive symptoms of PD.

COMMITTEE MEMBERS:
Presidente - 2140860 - ROVENA CLARA GALVAO JANUARIO ENGELBERTH
Externo à Instituição - JOSE RONALDO DOS SANTOS - UFS
Externo à Instituição - PAULO LEONARDO ARAÚJO DE GÓIS MORAIS - UERN