Banca de QUALIFICAÇÃO: MAYARA JULLY COSTA DA SILVA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : MAYARA JULLY COSTA DA SILVA
DATE: 03/04/2024
TIME: 09:00
LOCAL: Sala de Aula 1 Psicobiologia
TITLE:

Cortical oscillatory dynamics and gait when cycling in Parkinson's disease

KEY WORDS:

 Parkinson's disease; Gait; Cortical Oscillations; Cycling.

PAGES: 86
BIG AREA: Ciências Humanas
AREA: Psicologia
SUBÁREA: Psicologia Fisiológica
SPECIALTY: Psicobiologia
SUMMARY:

Many individuals with Parkinson's Disease (PD), despite severe motor deficits and freezing of gait, preserve the ability to ride a bicycle without difficulties. This is still an open and intriguing question for our understanding of how the neural network of human locomotion operates. The findings reveal that the beta oscillations of the basal ganglia and sensorimotor cortex are altered in PD, exhibit an exacerbated synchronization during voluntary movement and cause the motor signs and symptoms of the disease. Studies since 2010 have shown that these pathological beta oscillations are suppressed when cycling. Cycling also brings benefits to cardiovascular fitness, motor skills, general coping, feelings of independence, social inclusion and cognitive abilities in people with the disease. From this perspective, the objective of this study is to understand the immediate effects of pedaling a stationary bicycle on cortical oscillations and gait in people with PD. This is a blind, randomized and controlled clinical trial. To this end, a movement protocol (single session) was carried out by pedaling a stationary bicycle at low cadence (40-50 rpm) in a person with PD. This consisted of alternating blocks, lasting two minutes each, of rest and walking and cycling movements. The individual walks with preferred cadence on a ZENO electronic walkway (5 meters) for protokinetics movement analysis before and after pedaling on a horizontal stationary exercise bike, using a 16-channel scalp electroencephalogram (EEG) cap, following the international standard 10-20. For this, spatiotemporal characteristics of gait and cortical oscillations are investigated at rest (baseline), before and immediately after cycling in people with PD. The study design allows testing the immediate effects of cycling on gait and intra-subject neural oscillations, in addition to randomizing the groups that cycle once or twice. To implement the protocol, a bicycle synchronization system and interaction interface with the person pedaling were created, using a “Hall” effect sensor connected to the Arduino board and processing in Python language. This system provides feedback, easy and in real time, so that the person pedaling maintains the cadence between 40-50 rpm. In addition to providing data on cadence, experiment time (ms) and movement variation at the end of the exercise. 

The protocol was tested and proved to be effective for collecting EEG data and gait parameters in people with PD. Preliminary data analysis of EEG signals and spatio-temporal gait parameters were carried out to confirm this. Therefore, this study can help to understand how the cortical oscillatory dynamics of individuals with PD operate after cycling and the immediate effects on gait, as well as establishing relationships. Thus, it can support future implementations of clinical strategies that are easy to access, low-cost and non-invasive for the population with Parkinson's Disease.

COMMITTEE MEMBERS:
Presidente - 1216466 - JOHN FONTENELE ARAUJO
Interna - 6346130 - MARIA BERNARDETE CORDEIRO DE SOUSA
Externo ao Programa - 019.450.784-05 - HOUGELLE SIMPLICIO GOMES PEREIRA