Banca de DEFESA: GÊNEDY KARIELLY DA SILVA APOLINÁRIO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : GÊNEDY KARIELLY DA SILVA APOLINÁRIO
DATE: 12/07/2023
TIME: 14:00
LOCAL: Sala de Aula da Psicobiologia
TITLE:

Role of hippocampal CaMKII in object recognition memory processing

KEY WORDS:

CaMKII, Memory, Reconsolidation

PAGES: 110
BIG AREA: Ciências Humanas
AREA: Psicologia
SUMMARY:

Consolidation stabilizes learned information in long-term memories (LTM) through a protein synthesis and gene expression dependent process. LTM can be destabilized when recalled and must go through a “de novo” protein synthesis and gene expression dependent process called reconsolidation. Reconsolidation takes place in two phases and acts on an already existing mnemonic trace. The first phase, named destabilization, leaves the reactivated mnemonic trace in a malleable and modifiable state, while the second one, named restabilization, allows the mnemonic trace to become stable again. Object recognition memories (ORM) are declarative representations essential for remembering common sense information and autobiographical episodes. In fact, one of the first symptoms of Alzheimer's disease is a decline in this type of memory. In recent decades, the study of hippocampal synaptic proteins has been fundamental for a better understanding of the molecular mechanisms of memory. However, the role of these proteins in ORM reconsolidation remains inconclusive. We investigate the role of hippocampal calcium/calmodulin-dependent protein kinase II (CaMKII) in ORM processing. Our results shows that in rats (1) CaMKII is required for ORM consolidation, CaMKII activity is necessary for ORM destabilization, but not for ORM restabilization, (2) ORM destabilization requires GluN2B NMDAr activity to occur, suggesting an important interplay between CaMKII and NMDAr, (3) ORM destabilization induces coupling of theta-gamma oscillation which is blocked by CaMKII inhibition. We understand that CaMKII activity is unprecedented for physiological processes and, therefore, that the understanding of CaMKII role in memory is crucial to the better comprehension of how neurological disorders develop.

COMMITTEE MEMBERS:
Presidente - 1996111 - MARTIN PABLO CAMMAROTA
Interna - 1645202 - ELAINE CRISTINA GAVIOLI
Externa ao Programa - 1720860 - VANESSA DE PAULA SOARES RACHETTI - UFRNExterno à Instituição - JORGE HORACIO MEDINA - UBA
Externa à Instituição - GRACE SCHENATTO PEREIRA MORAES - UFMG