Banca de QUALIFICAÇÃO: HELOYSA ARAÚJO SILVA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : HELOYSA ARAÚJO SILVA
DATE: 16/11/2022
TIME: 09:00
LOCAL: online
TITLE:

BEHAVIOURAL VARIATION ALONG THE BOLD-SHY CONTINUUM: HOW DIFFERENT PROFILES COULD CONTRIBUTE TO UNDERSTANDING LICIT DRUGS ADDICTION

KEY WORDS:

 neurophysiology, behaviour, alcohol, nicotine, cannabidiol, ontogeny

PAGES: 70
BIG AREA: Ciências Biológicas
AREA: Fisiologia
SUMMARY:

 

The WHO reports estimate that 3.3 million people die from alcohol-related causes each year, while cigarette smoking is responsible for another 8 million deaths, making these the most impactful and deleterious drugs worldwide. Both alcohol and nicotine affect the central nervous system, interacting with neurotransmission systems such as the dopaminergic (mainly involved in reinforcing the behaviour and addiction). Excessive and chronic consumption of both these drugs can lead to a state of dependence and abuse, with diverse behavioural and cognitive effects. However, not all people respond in the same way to substances: it is known that there are genetic, physiological, and behavioural variations that influence how subjects develop drug dependence. Comparative studies between groups of individuals with different behavioural and physiological characteristics are necessary because they help understand how the genetic background contributes to the effects of drugs and the development of abusive use. To study how alcohol and nicotine affect humanity, several laboratories are conducting research using one of the most popular animals for translational research: the zebrafish (Danio rerio). This model offers the possibility of translational conclusions, as it has biochemical pathways that have been evolutionarily conserved in humans, making it ideal for studying drug addiction. Furthermore, the model's predictive validity allows the testing of alternative treatments, including cannabinoids and polyphenols. This proposal aims to evaluate behavioural and cognitive responses and gene expression due to acute and chronic exposure to alcohol and nicotine among different zebrafish individuals during ontogeny and evaluate treatments with bioactive metabolites in the active search behaviours in these individuals.

 

COMMITTEE MEMBERS:
Presidente - 1644341 - ANA CAROLINA LUCHIARI
Externo à Instituição - CAIO MAXIMINO
Externa à Instituição - MARTA CANDEIAS SOARES - UNIPORTO