Banca de DEFESA: MARLON BARBOSA DANTAS DE CARVALHO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MARLON BARBOSA DANTAS DE CARVALHO
DATE: 22/10/2020
TIME: 14:00
LOCAL: Videoconferência
TITLE:

Participation of the hypothalamus-hypophysis-adrenal axis in modulating the depressive type behavior induced by the activation of nociceptin/orphanin FQ receptor

KEY WORDS:
PAGES: 58
BIG AREA: Ciências Humanas
AREA: Psicologia
SUMMARY:

Several studies have linked the N/OFQ-NOP receptor system with depressed mood disorder. Despite the notorious antidepressant effects of NOP antagonists in different behavioral tests and animal models of depression, little is known about the behavioral actions of NOP agonists under stress conditions. The present study aimed to investigate the participation of the hypothalamic-pituitary-adrenal (HPA) axis in the NOP agonist-induced depressive-like behaviors in mice treated prior to the first exposure to the forced swim test. The effects of the treatment with the tricyclic antidepressant nortriptyline, a NOP agonist (Ro 65-6570) and a NOP antagonist (SB-612111) before exposure to forced swimming stress was investigated. In addition, in order to evaluate the participation of the HPA axis in the effects of the NOP agonist (Ro 65-6570) in the forced swim stress, mice were pretreated with CRF1 receptor antagonist (NBI 30755), glucocorticoid receptor antagonist (mifepristone) and glucocorticoids synthesis inhibitor (aminoglutethimide). Firstly, the administration of the nortriptyline prior to exposure to the forced swim did not affect mouse behavior when compared to the control group. However, an increase in the immobility time was observed in mice treated with the NOP agonist, Ro 65-6570, while a decrease in the immobility time was detected in those animals treated with the NOP antagonist, SB-612111, being both drugs administered before stress, when compared to the control group. Finally, it was observed that the effects of Ro 65-6570 in the immobility time were blocked when mice were pretreated with mifepristone, NBI 30755 or aminoglutethimide. However, there were no effects of the HPA axis blocking agents per se on the behavior of mice in the forced swim stress. In conclusion, the activation of NOP receptor promotes depressive-like effects, while the blockade produces opposite effects. In addition, the depressive-like effects of NOP agonists appear to be mediated by the HPA axis.

BANKING MEMBERS:
Presidente - 1645202 - ELAINE CRISTINA GAVIOLI
Interno - 811.318.790-15 - FABIANO PERES MENEZES - UFRN
Externa à Instituição - JULIA JENSEN DIDONET - UNIP