Banca de DEFESA: MIRELLA SALGUES DE CARVALHO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MIRELLA SALGUES DE CARVALHO
DATE: 06/10/2020
TIME: 09:00
LOCAL: Videoconferência
TITLE:

Behavioral effects of tamsulosin - selective α1A adrenoceptor antagonist - in mice

KEY WORDS:
PAGES: 66
BIG AREA: Ciências Humanas
AREA: Psicologia
SUMMARY:

Tamsulosin is the main form of treatment of urinary symptoms in patients with benign prostatic hyperplasia. This selective α1A adrenoceptor antagonist acts on both smooth muscle cells of the prostate and in other regions of the central nervous system. Studies suggest that the use of this drug can increase the likelihood of developing depression, dementia and anxiety in treated patients, possibly because tamsulosin can cross the blood-brain barrier. A recent study used DAT-IRES-Cre knock-in animals to evaluate the role of the limbic system in modulating resilience to stress and the results suggested that adrenoceptors play an important role in this process. In addition, it has been shown that transgenic mice expressing constitutively active mutant α1A adrenoceptors presented antidepressant-like phenotype and improvements on general cognition. In the present study, we sought to evaluate the effects of acute treatment with tamsulosin in male mice behavior through forced swim test, elevated plus maze and open field. The results obtained show that tamsulosin was capable of promoting hypolocomotion in the animals treated with the dose of 0,1 mg/kg; it was capable of promoting and increase in immobility time in mice treated with the doses of 0,01 mg/kg and 0,1 mg/kg; and it was not capable of altering the percentage of number of entries, the percentage of time spent at the open arms nor the number of entries on the closed arms. In conclusion, this study points a possible relation between tamsulosin and an increase in vulnerability to stress, which could explain the apparent pro-depressive effect as a result of the use of this medication by patients with BPH.

BANKING MEMBERS:
Presidente - 1645202 - ELAINE CRISTINA GAVIOLI
Externo ao Programa - 2412258 - EDILSON DANTAS DA SILVA JUNIOR
Externa à Instituição - ISABELLA MARIA DE OLIVEIRA PONTES FERNANDES - UFERSA