Banca de DEFESA: LUIZ EDUARDO MATEUS BRANDÃO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : LUIZ EDUARDO MATEUS BRANDÃO
DATE: 29/05/2020
TIME: 08:00
LOCAL: Videoconferência
TITLE:

6-OHDA effects on rest-activity rhythms and the circadian expression of histamine in the central nervous system of rats

KEY WORDS:

Parkinson Disease; non-motor symptoms; histamine; circadian disruption; bmal1; non-parametric analysis

PAGES: 100
BIG AREA: Ciências Humanas
AREA: Psicologia
SUMMARY:

Parkinson Disease (PD) is a neurodegenerative disease mainly characterized by a progressively dopaminergic depletion on central nervous system (CNS). Furthermore, PD patients exhibit non-motors symptoms like sexual dysfunction, cognitive impairment, olfactory damage, depression, anxiety, sleep disturbs, circadian disruptions and others signs. These non-motors symptoms are result of neurochemical changes in others neurotransmission circuitries like noradrenergic, cholinergic, serotoninergic and/or histaminergic systems. Human post mortem studies showed alterations in histaminergic receptors and neural projections distribution throughout the CNS of PD patients. Moreover, studies based on neurotoxin infusion reinforced this relationship between the histaminergic system and the physiopathology process of PD. In mammals, the histaminergic system controls alertness and wakefulness status, acting as an essential component of sleep-wake regulatory system. Here, we used an intracerebroventricular infusion of 6-hydroxydopamine as a pharmacological tool to induce rest-activity rhythm fragmentation and investigated what types of rhythmic parameters were affected and how the wake-promoter histaminergic system contributes with this phenomenon. Our protocol induced a progressive rest-activity rhythm impairment, without changing histidine decarboxylase or bmal1 protein expression in tuberomammilary or suprachiasmatic nucleus. Parametric and non-parametric rhythm analyses were conducted to describe the impairment of rest-activity rhythm as a progressive circadian dysfunction with increased fragmentation/variability on animal activity throughout the day, as well as a reduced stability of this activity pattern between consecutive days within both entrained and constant conditions (i.e. light-dark and constant darkness schedules, respectively). We conclude that dopamine exerts an important role on rest-activity rhythm regulation, in both synchronized and constant photoperiods, without affecting the histaminergic tonus.

BANKING MEMBERS:
Externo à Instituição - FELIPE PORTO FIUZA - IINN
Presidente - 2351800 - JEFERSON DE SOUZA CAVALCANTE
Interno - 2998660 - MARIO ANDRE LEOCADIO MIGUEL
Externo à Instituição - MAXWELL BARBOSA DE SANTANA - UFOPA
Externa à Instituição - YWLLIANE DA SILVA RODRIGUES MEURER - UFPB