Banca de QUALIFICAÇÃO: JORGE ALEXANDER RIOS FLOREZ

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : JORGE ALEXANDER RIOS FLOREZ
DATE: 06/12/2019
TIME: 14:00
LOCAL: Sala de Reuniões do DMOR
TITLE:

Neuroanatomic substrate of the cognitive and visceromotor circuits of the medial prefrontal cortex; Description of their projections and interactions with the amygdaloid, hypothalamic and hippocampal complexes in non-human primates.

KEY WORDS:

Amygdala; Hippocampus; Hypothalamus; Infralimbic; Limbic system; Neurons; Medial prefrontal cortex; Neuronal tracing; Pre-limbic.

PAGES: 102
BIG AREA: Ciências Humanas
AREA: Psicologia
SUMMARY:

The interest of science, and particularly of the fields of biology and neuroscience, is in understanding the functioning of the nervous system in relation to the products of brain activity, such as cognition and behavior, has led to the development of several investigations that put their focus of study in the frontal lobes, especially in the prefrontal regions. The dorsolateral, medial and orbito prefrontal cortex have been functionally studied; however, the anatomical projections of the axons and the description of the neural networks that originate in these areas of the brain have brought more interest in some than in others. With that being said, the medial region of the prefrontal lobes have not received sufficient attention in the approach and detail of its projections and relations with the subcortical structures of the brain, among which the tonsils and hippocampus are noted for having a functional relationship when considering the manifestations clinics of neurological and neuropsychological syndromes resulting from medial prefrontal cortex damage. Therefore, this research proposal is aimed to establish the neuroanatomic substrate of the cognitive and viscera motor circuits of the medial prefrontal cortex and their projections and interactions with the amygdaloid, hypothalamic and hippocampus complexes in non-human primates. The research developed is presented as a comparative descriptive study, with non-probabilistic sampling, considering the use of the primate as an animal study model, of the species Callithrix Jacchus (known as Marmoset). As a technique to track nerve cells, the technique of axon marking, antegrade marking was used; deposited in the pre-limbic (PL) and infralimbic (IL) cortices of the medial prefrontal cortex. Among the planned hypotheses, it was proposed that there is an organized distribution in the directionality of the fibers towards the subcortical regions associated with the three complexes of interest, in non-human primates, a fact that was possible to corroborate from the results obtained. Most of the areas and nuclei of the hypothalamic and amygdaloid complex received fibers of both cortices (PL and IL), at different densities, but in the hippocampus complex the fibers were restricted to PL projections. It was also possible to determine the pattern of rostral-caudal density of the fibers in these areas, as well as to identify that the groups of fibers that come from the IL are more organized within the complexes, than the groups that originate in the PL. As said stated before, the intention of contributing to the elucidation and extrapolation of the anatomical-functional correlates of brain activity and broadening their understanding.

BANKING MEMBERS:
Presidente - 4363493 - EXPEDITO SILVA DO NASCIMENTO JUNIOR
Externo à Instituição - FERNANDO VAGNER LOBO LADD - USP
Externo à Instituição - PAULO LEONARDO ARAÚJO DE GÓIS MORAIS - UERN