Banca de QUALIFICAÇÃO: MARLON BARBOSA DANTAS DE CARVALHO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : MARLON BARBOSA DANTAS DE CARVALHO
DATA : 14/03/2019
HORA: 10:00
LOCAL: Sala Darwin
TÍTULO:

ESTUDO DA PARTICIPAÇÃO DO EIXO HIPOTÁLAMO-HIPÓFISE-ADRENAL NA MODULAÇÃO DO COMPORTAMENTO TIPO DEPRESSIVO INDUZIDO PELA ATIVAÇÃO DE RECEPTOR DE NOCICEPTINA/ORPHANINA FQ

PALAVRAS-CHAVES:

depression; nociceptin/orphanin FQ; mouse; forced swimming.

PÁGINAS: 22
GRANDE ÁREA: Ciências Humanas
ÁREA: Psicologia
RESUMO:

Several studies have related the N/OFQ-NOP receptor system with depressive mood disorder. Despite the notorious antidepressant-like effect induced by the administration of NOP antagonists in different behavioral tests and animal models of depression, little is known about the behavioral action of NOP agonists under stress conditions. Very recent evidence from our research group has shown that the administration of NOP agonists facilitates depressive-like behavior in mice in the model of learned helplessness. This model is well validated for the study of depression, but the animal is submitted to 180 electroshocks on the legs in order to promote the acquisition of depressive behavior. In this project, we intend to evaluate the role of NOP agonists in the acquisition of the depressive phenotype in the forced swimming test, which is a much less stressful condition when compared to the model of learned helplessness. Furthermore, we aimed to evaluate the participation of the hypothalamic pituitary-adrenal axis (HPA) in mediating this depressor-like effect induced by NOP agonists. To achieve this goal, we will test the effect of 2 NOP agonists (Ro 65-6570 and MCOPPB) and a NOP antagonist (SB-612111) in animals pretreated with CRF1 receptor antagonist (NBI 30755), glucocorticoid (RU 486) and glucocorticoid synthesis inhibitor (aminoglutethimide). For comparison purposes, the action of dexamethasone will be evaluated in this same experimental condition. It was initially observed that treatment with imipramine confirmed and standardized our experimental condition. Administration of dexamethasone prior to training did not change the immobility time of the animals compared to the control. NOP agonist pre-treatment, Ro 65-6570, significantly increased the animals' immobility time while NOP antagonist pre-treatment, SB-612111, induced a decrease in the immobility time of the animals in the initial tests performed. This work is expected to advance the understanding of the role played by the HPA axis in mediating depressive behavior induced by NOP agonists.

MEMBROS DA BANCA:
Presidente - 1645202 - ELAINE CRISTINA GAVIOLI
Interno - 2190521 - HINDIAEL AERAF BELCHIOR