Banca de QUALIFICAÇÃO: FERNANDA CARVALHO CAGNI

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : FERNANDA CARVALHO CAGNI
DATA : 04/12/2017
HORA: 15:00
LOCAL: Sala de Reuniões do Centro de Biociências
TÍTULO:

EFFECTS OF THE NOP RECEPTOR ANTAGONIST SB-612111 IN THE SOCIAL DEFEAT MODEL

PALAVRAS-CHAVES:

Antidepressant; anxiolytic; NOP receptor antagonists; social defeat model; Nociceptin/orphanin-FQ; mice.

PÁGINAS: 44
GRANDE ÁREA: Ciências Humanas
ÁREA: Psicologia
RESUMO:

Social defeat is an ethologically relevant stressor that is based on the natural establishment of hierarchy in male mice. Nociceptin/orphanin FQ (N/OFQ) is an endogenous peptide that binds to a protein G inhibitory receptor named NOP. Studies have shown that NOP receptor antagonists display antidepressant actions. However, limited information is available about the effects of NOP antagonists in rodents subjected to an animal model of depression. The aim of this study is to investigate if the NOP receptor antagonist SB-612111 can prevent the development of behavioral changes and/or reverse them once they are installed. Swiss male mice were submitted to 10 days of social defeat (SD). After 5 days of SD, animals showed slight behavioral changes that were marginally significant. Nevertheless, after 10 days of SD, mice presented a longer immobility time in the tail suspension test, spent less time in the center of the open field test, and they lost weight. In addition, no behavioral alterations were detected in the social interaction test. In another experimental series, 7-day Venlafaxin treatment, a classic antidepressant, initiated in the 5ª day of SD, did not prevent depressive and anxious-like behavior and weight loss. In the future, we will test the effect of SB-612111 in the prevention of SD-induced behaviors. In order to investigate the effects of the drug treatments on SD-induced depressive/anxious phenotype, a 7- day treatment with Venlafaxin or SB 612111 will begin after the 10 days SD. Finally, we will investigate the biochemical changes related to oxidative damage in the hippocampus and prefrontal cortex, and the neuronal consequences assessed by immunohistochemistry resulted from SD exposure and/or proposed treatment actions. In conclusion, preliminary data suggest that the SD is a good model for the investigation of antidepressive/anxiolytic potential of a compound, since promotes robust behavioral changes that were replicated in our experimental conditions.

MEMBROS DA BANCA:
Interno - 1696755 - BRUNO LOBAO SOARES
Presidente - 1645202 - ELAINE CRISTINA GAVIOLI
Interno - 2140860 - ROVENA CLARA GALVAO JANUARIO ENGELBERTH