Banca de DEFESA: FLÁVIA SANTOS DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : FLÁVIA SANTOS DA SILVA
DATA : 05/07/2017
HORA: 14:30
LOCAL: Sala de Aula da Pós-Graduação em Psicobiologia
TÍTULO:

NÃO INFORMADO.

PALAVRAS-CHAVES:

Translational animal model; Non-human primate; Neuroendocrinology; Juvenile depression; Psychedelic substances.

PÁGINAS: 82
GRANDE ÁREA: Ciências Humanas
ÁREA: Psicologia
RESUMO:

The Major Depression (MD) is a worldwide mood disorder, reaching approximately 300 million people, capable of induce psychological, social and physiological impair, which in some cases can lead to death by suicide. 14% of young people aged 15-18 have DM that provoke attention and apprehension, since this phase consist an ontogenetic period of major brain modifications that last for the all lives. Currently, the most commonly used antidepressant treatment in all age groups is the pharmacological, although the new classes of antidepressants are more specific in their action, still have considerable side effects, take up to two weeks to initiate the desired therapeutic effects and induce low rate of remission. Thereby, there is a necessity to seek new pharmacological treatments for DM. In this scenario, have been tested some psychedelic serotonergic substances. The ayahuasca tea, a traditional Amazonian tea, has particularly drawn attention by its positive effects on health, both in the general population of users and in patients with mood disorders and drug addicts. To test the acute antidepressant action of ayahuasca was used Callithrix jacchus, a non-human primate that has already been considered an important model in biomedical studies, including mental disorders, because it´s more phylogenetic proximity to humans, has a well-defined etogram, invasive methods for measuring cortisol in feces, good adaptation in captivity and high fecundity rate. However, it was initially necessary to validate the species as a translational model of juvenile depression. For this, it was used the protocol of chronic social isolation that induced a physiological and behavioral depression-like state in males and females juvenile of C. jacchus, which was largely reversed by treatment with a classic antidepressant, nortriptyline (7 days). This study and its results are described in article I entitled " Common marmosets: A translational animal model of juvenile depression". Then was tested the acute antidepressant potential of ayahuasca tea in the previously validated translational model and after that we compared its efficacy with nortriptyline and placebo (saline). Thus, was originated the article II entitled " Acute effect of Ayahuasca tea on hormonal and behavioral parameters in common marmosets, as juvenile non-human primate model of depression". In both treatments was observed that (ayahuasca and nortriptyline) induced improvements in part of depressive-like symptoms, which was not observed with placebo. However, ayahuasca tea presented more effective antidepressant results than nortriptyline, since it started to revert symptoms faster, adjusted and lasting. Both studies presented here are of great relevance to the area, since in an unpublished way a translational model met all validation criteria, both traditional ones, such as; the etiological, face, functional and predictive, as well as the more recent criteria: inter-relational, evolutionary and population, thus enabling its use in complementary areas of investigation. In addition, it was emphasized not only acute antidepressant actions of the ayahuasca tea, but also more effective actions compared to the classic antidepressant, nortriptyline, thus corroborating in the validation process of this drug as antidepressant, stimulating new pharmacological investigations in this line that allow the consolidation of this substance as an antidepressant, since it has not shown tolerance to doses and nor long-term side effects in recreational users.

MEMBROS DA BANCA:
Interno - 1696755 - BRUNO LOBAO SOARES
Externo à Instituição - MARÍLIA BARROS - UnB
Presidente - 1718518 - NICOLE LEITE GALVAO COELHO