Banca de DEFESA: JOACIL GERMANO SOARES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : JOACIL GERMANO SOARES
DATA : 22/12/2016
HORA: 14:00
LOCAL: Sala de Aula da Pós-Graduação em Psicobiologia
TÍTULO:

NÃO INFORMADO.

PALAVRAS-CHAVES:

Nociception; Ketamine and Xylazine; isoflurane; C-Fos; peritonitis.

PÁGINAS: 98
GRANDE ÁREA: Ciências Humanas
ÁREA: Psicologia
RESUMO:

The periaqueductal gray (PAG), parabrachial nuclei (PB), solitary nucleus (SOL) and LC (locus coeruleus) are important sites for modulation of nociception. These regions receive afferent nociceptive neurons of the spinal cord and projects to the thalamic nucleus, often modulating this information. Such as Paraventricular the thalamus (PV), central medial thalamic nucleus (CM), mediodorsal thalamic nucleus (MD), paracentral thalamic nucleus (PC), centrolateral thalamic nucleus (CL) and from there to other parts of the brain stem and the cerebral cortex. Three groups of animals were used, with five individuals in each group being divided as follows: a control group, a group ketamine + xylazine and isoflurane group. Transcardially perfused were 90 minutes after the on set of peritonitis with acetic acid. Immunohistochemistry was performed for C-Fos and the collected data were statistically analyzed using SPSS software 20 was considered significant p ≤ 0.05. Analyzing each nuclei separately compared between the groups revealed the following results: Ketamine and xylazine acted in stimulating neurons in the PV nuclei, MDM and CDM. However decreased activity on PC nuclei, here more effectively than isoflurane. In PAG, CP and SOL isoflurane was more effective in decreasing neuronal activity compared to ketamine and xylazine. In the CM and CL all drugs acted quantitatively similar decreasing neuronal activity. While the LC there was no significant difference, which suggests that all tested drugs had good performance in this nucleus. So we could say that the combination of isoflurane, ketamine and xylazine, perhaps the most appropriate protocol for anesthesia, taking into account only these three drugs. Since ketamine and xylazine were as characteristic increase neuronal activity in those neuronal nuclei which are known modulators, that is, increases the activity of neurons that will inhibit nociceptive information, while the isoflurane had a better performance in neuronal relay nuclei to other areas. Thus, it seems that ketamine and xylazine act complementing the action of isoflurane in the brainstem.

MEMBROS DA BANCA:
Externo à Instituição - EUDES EULER DE SOUZA LUCENA - UERN
Presidente - 4363493 - EXPEDITO SILVA DO NASCIMENTO JUNIOR
Interno - 2351800 - JEFERSON DE SOUZA CAVALCANTE
Externo à Instituição - JOSÉ RODOLFO LOPES DE PAIVA CAVALCANTI - UERN
Externo à Instituição - MELQUISEDEC ABIARE DANTAS DE SANTANA - UFRN