Banca de QUALIFICAÇÃO: FABRICE TAIO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : FABRICE TAIO
DATE: 22/03/2024
TIME: 14:00
LOCAL: Link de acesso para videoconferência: https://meet.google.com/keu-zbmt-uca
TITLE:
INCLUSION COMPLEX BETWEEN COPAÍBA OIL (Copaifera multijuga Hayne)
AND HPGCD: DEVELOPMENT AND CHARACTERIZATION FOR ANTI
TRYPANOSOMA CRUZI

KEY WORDS:
Inclusion complexes, cyclodextrins, copaiba oil, Copaifera multijuga Hayne, Anti Trypanosoma cruzi.

PAGES: 131
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
Chagas disease is a contagious disease caused by a parasite and transmitted mainly through the
insect known as "kissing bug". The transmission of the causative agent of Chagas disease to
humans is influenced by a series of factors, including disordered migration, manipulation of the
environment, climate change and population concentration in urban areas. Therefore, it is
necessary to carry out in-depth studies to find a treatment that is more effective than existing
treatments. The alternative for our research was copaíba oil of the copaíba multijuga hayne type,
which belongs to the Leguminosae-Caesalpinioideae family. The objective of the research is to
incorporate the copaiba oil multijuga hayne in a polymer such as cyclodextrin of the
hydroxypropyl type of γ-cyclodextrin, with the aim of increasing its solubility and bioavailability
for better interaction with cultured cell samples from the T-cruzi strain. γ-cyclodextrin
(OLC/HPGCD) were prepared by physical mixing and malaxing methods. The complex results
were characterized using optimized physicochemical methods.Differential Scanning Calorimetry
(DSC) tests were carried out to observe the incorporation of OLC when inserted into the HPGCD.
The DSC curves showed endothermic peaks related to water loss. HPGCD had an endothermic
peak at 70°C which is attributed to the evaporation of water molecules from the HP-γ-CD cavity
while OLC had an endothermic peak at 110°C which is attributed to its volatilization effect. The
DSC curves of physical mixing and malaxing had peaks at 66°C and 60°C respectively,
approximately close to the endothermic peak of HPBCD. MF and MLG are practically similar to
the HPGCD curve and totally different from the OLC. The X-ray diffraction analysis (XRD) tests
of HPGCD, MF and MLG gave a striking result with the appearance of 3 sharp peaks, 1 of which
was of maximum intensity and two of much lower intensity. The diffraction profile of HPGCD
gave a peak of 43.92 °C, MF and MLG gave 43.94 °C for maximum intensity of 1610, 1388 and
2102 respectively, with MLG having a peak whose intensity is higher. The XRD allowed us to
observe the appearance of amorphous in all joints with crystalline ones.The curves of the
structural analysis by Fourier transform infrared spectroscopy (FTIR) of HPGCD and OLC
showed 7 bands and 5 main bands respectively. Thanks to the measurement of the peaks on the X
axis, we were able to create a table with wave number values
in the spectra. Basically, the FTIR
profiles of MF and MLG had the disappearance of the OLC peaks at 800, 1449, 2584. Thus, the
HPGCD bands masked those of the OLC. Thus, these physicochemical characterizations allowed
us to conclude that there was an interaction between OLC and HPBCD. In the future , the samples
were used for in vivo antiparasitic testing.

COMMITTEE MEMBERS:
Externo à Instituição - BOLIVAR PONCIANO GOULART DE LIMA DAMASCENO - UEPB
Presidente - 1893445 - EUZEBIO GUIMARAES BARBOSA
Externo ao Programa - 2140814 - FERNANDO HENRIQUE ANDRADE NOGUEIRA - null
Notícia cadastrada em: 07/03/2024 17:26
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