Banca de QUALIFICAÇÃO: SÁVIO GORGÔNIO PAES DE BULHÕES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : SÁVIO GORGÔNIO PAES DE BULHÕES
DATE: 30/11/2023
TIME: 14:00
LOCAL: Link de acesso para videoconferência: https://meet.google.com/gvd-kaje-keh
TITLE:
AMORPHOUS SOLID DISPERSIONS WITH NEW TRITERPENE

KEY WORDS:
Solid dispersions; α, β-amirenone; Hydrophilic polymers; Triterpenes; Lipase.

PAGES: 65
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
α, β-amirenone (ABAME) is a triterpene mixture with high anti-obesity potential, but its
low water solubility makes its use difficult. However, the development of solid
dispersions (DS) with hydrophilic polymers has demonstrated satisfactory results in
increasing the aqueous solubility of drugs. Therefore, this study aims to develop DS
using Polyethylene glycol 6000 (PEG) and Polyvinylpyrrolidone K30 (PVP) with
ABAME, characterize them by DSC, TG, XRD, FTIR and SEM techniques and evaluate
their antilipase biological activity in vitro. The DSC results indicate a decrease in
ABAME crystallinity after the formation of DS. The TG results demonstrate that the
polymers provided greater thermal stability to ABAME. Furthermore, DS showed a
reduction in crystalline reflections compared to polymers and ABAME, suggesting a
change to the amorphous state, confirmed by SEM images. The lipase inhibition
activity test demonstrated a great anti-obesity potential of ABAME.

COMMITTEE MEMBERS:
Presidente - 1492900 - CICERO FLAVIO SOARES ARAGAO
Externo à Instituição - EDUARDO PEREIRA DE AZEVEDO - UnP
Externo à Instituição - EMERSON SILVA LIMA - UFAM
Notícia cadastrada em: 13/11/2023 18:24
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