Banca de DEFESA: CEZAR SILVINO GOMES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : CEZAR SILVINO GOMES
DATE: 21/11/2023
TIME: 08:30
LOCAL: Link de acesso para videoconferência: https://meet.google.com/eku-guuy-ycn
TITLE:
Three years of wastewater surveillance for new psychoactive substances from 16 countries

KEY WORDS:
Sewage-Based Epidemiology; Cocaine; MDMA; Ecstasy; Carnatal 2019; Carnival 2020.

PAGES: 228
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
Illicit drugs and other substances consumed by humans are metabolized and excreted in urine,
and they can be quantified in wastewater through Solid Phase Extraction (SPE) and Liquid
Chromatography-Tandem Mass Spectrometry (LC-MS/MS). By knowing the population size,
the sampled wastewater volume, and the excretion rates of their metabolites, it is possible to
calculate the amount of drug consumed from the measurement of these metabolites. This
method, known as Wastewater-Based Epidemiology (WBE), was used to diagnose the use of
cocaine and MDMA in Natal, RN, and João Pessoa, PB. The research highlights some of the
advantages and disadvantages of the WBE tool. WBE can bring valuable insights to public
health and safety and directly impact public campaigns for drug addiction prevention and the
mitigation of associated environmental pollution. Calibration curves were constructed through
linear regressions using deuterated internal standards. Statistical tests were utilized to eliminate
outliers, assess homoscedasticity (Cochran test), and evaluate the model's adequacy and work
range (lack-of-fit). The results showed an average consumption of 263 mg/1000 inhabitants/day
for cocaine and 18 mg/1000 inhabitants/day for MDMA during Carnatal (2019) and 3400
mg/1000 inhabitants/day for cocaine and 60 mg/1000 inhabitants/day for MDMA during
Carnival (2020). During festive events, consumption increased by approximately two times
compared to the previous week. Cocaine consumption during the 2020 Carnival in Natal ranged
between 1.6 and 5.8 g/day/1000 inhabitants, and in a typical week in 2022, it ranged between
1.3 and 4.6 g/day/1000 inhabitants. The concomitant consumption of alcohol and cocaine was
also evidenced by the presence of the metabolite cocaethylene, a substance more toxic than
cocaine and ethanol, which should be a concern for public health. During the Christmas
festivities and the 2021-2022 New Year's Eve, the presence of mitragynine and 25I-NBOH was
detected in wastewater. In April 2022, cocaine consumption in João Pessoa, PB, fluctuated
between 2.1 and 2.7 g/1000 inhabitants/day. The study provided relevant information for health
and public safety managers, demonstrating the almost real-time applicability of the technique,
while also highlighting limitations associated with sample preparation. Above all, the research
demonstrated the validity of using the WBE tool as a complementary means to monitor the
consumption of illicit substances.

COMMITTEE MEMBERS:
Externa à Instituição - HADASSA DE SOUZA RAMOS PONTES MOURA - UnB
Interno - 1571756 - ALESSANDRO KAPPEL JORDAO
Externo à Instituição - ALEXANDRO MANGUEIRA LIMA DE ASSIS - UFAL
Presidente - 1492900 - CICERO FLAVIO SOARES ARAGAO
Externo à Instituição - FERNANDO FABRIZ SODRÉ - UnB
Externo ao Programa - 2140814 - FERNANDO HENRIQUE ANDRADE NOGUEIRA - null
Notícia cadastrada em: 01/11/2023 11:56
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