Banca de QUALIFICAÇÃO: ISABELLE CRISTINA CLEMENTE DOS SANTOS

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : ISABELLE CRISTINA CLEMENTE DOS SANTOS
DATE: 15/03/2023
TIME: 08:00
LOCAL: Link de acesso para videoconferência: https://meet.google.com/usc-wpep-fia
TITLE:
Painel of SNPs to assess the risk and prognosis of thyroid carcinoma in a mixed population

KEY WORDS:
thyroid, cancer, SNP, predisposition, prognostic.

PAGES: 118
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
Thyroid cancer (TC) is the most common endocrine tumor and accounts for 1% of all
malignant neoplasms. Genotyping studies look for single nucleotide polymorphisms
(SNPs) that may be related to increased risk of TC and worst prognosis. Therefore, this
study aimed to evaluate a panel of SNPs would be associated with TC predisposition and
prognosis in a heterogeneous population from the State of Rio Grande do Norte/Brazil.
Thyroid biopsies were selected from 279 TC patients and peripheral blood samples were
collected from 301 healthy donor volunteers from the blood. Genotyping of a panel of 84
SNPs was performed in both groups using the MassARRAY SNP system. The SNPs
rs10759944, rs7850258, rs116909374 and rs34566348 were associated with the risk of
developing TC. Regarding the factors associated with TC prognosis, It was observed that
rs2236487 was associated with risk of papillary carcinoma and the rs1571443 was
associated with risk of follicular carcinoma. The rs31872 was associated with protection
from the development of tumors ≤ 2 cm. When evaluating the association of SNPs with
tumor staging, the rs10238549 was associated with the risk of developing stages I and II.
On the other hand, the rs7800391 was associated with protection from stage I and II
development. Furthermore, the rs949908 was associated with a risk of persistent TC, and
rs487880 were associated with a risk of developing metastasis. The present study, a
pioneer in a mixed population of northeastern Brazil, suggests the association of SNPs as
markers of predisposition and prognosis of TC in this population.

COMMITTEE MEMBERS:
Presidente - 1055045 - MARCELA ABBOTT GALVAO URURAHY
Externa ao Programa - 8347651 - MARIA DE FATIMA PAIVA BARACHO - UFRNExterno à Instituição - VICTOR HUGO REZENDE DUARTE - UNIFACEX
Notícia cadastrada em: 14/03/2023 11:06
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