Banca de QUALIFICAÇÃO: THAYSE EVELLYN SILVA DO NASCIMENTO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : THAYSE EVELLYN SILVA DO NASCIMENTO
DATE: 13/03/2023
TIME: 09:00
LOCAL: Link de acesso para videoconferência: http://meet.google.com/bbt-ntqc-qrp
TITLE:
Mass Spectrometric Identifification of Licania rigida Benth Leaf Extracts and Evaluation of Their Therapeutic Effects on Lipopolysaccharide-Induced Inflflammatory Response

KEY WORDS:
Licania rigida Benth; Medicinal plants; Anti-inflammatory.

PAGES: 63
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
The anti-inflammatory properties of Licania rigida Benth have been evaluated as an
alternative drug approach to treating several inflammatory processes. Thereby, in this
study, aqueous and hydroalcoholic extracts of L.rigida leaves were analyzed
regarding their phytocomposition by Ultra-Fast Liquid Chromatography coupled to a
mass spectrometry, and their anti-inflammatory properties were assessed by an in
vitro and in vivo inflammation model using Lipopolysaccharide as an inducer of the
inflammatory process . The phytochemical profile indicated gallic acid and ellagic
acid as an important constituent in both extracts, while isovitexin, ferulate, some
bulky amino acids (e.g. phenylalanine), pheophorbide, lactic acid and pyridoxine
were detected in hydroalcoholic extracts. The extracts displayed the ability to
modulate the in vitro and in vivo inflammatory response by changing the pro
inflammatory (TNF-α, IL-1β, and IL-6) cytokines secretion, also inhibiting the PD-1
secretion and NO production, as well as, inhibiting leukocyte migration. Overall, for
the first time, it was characterized by putative compounds from Licania rigida Benth
leaves, which can modulate the inflammatory process. Therefore, the data suggests
this plant as an option to obtain extracts for phytotherapic formulations to treat and/or
prevent chronic diseases.

COMMITTEE MEMBERS:
Interna - ***.474.624-** - KARLA SIMONE COSTA DE SOUZA - UFRN
Externa à Instituição - LARISSA MARINA PEREIRA SILVA - NCSU
Presidente - 1055045 - MARCELA ABBOTT GALVAO URURAHY
Notícia cadastrada em: 23/02/2023 14:41
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