Banca de DEFESA: LUIZ FERNANDO RODRIGUES DE SOUZA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : LUIZ FERNANDO RODRIGUES DE SOUZA
DATE: 24/09/2021
TIME: 09:00
LOCAL: Link de acesso para videoconferência: meet.google.com/yck-nmxs-obx
TITLE:

ESTUDO DOS METABÓLITOS BIOATIVOS DE INTERESSE FARMACÊUTICO EM Selaginella convoluta (ARN.) SPRING

KEY WORDS:

Caatinga, Selaginella convoluta, Proteome, Biosynthesis.

PAGES: 135
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Selaginella convoluta is a lycophyte native from Caatinga biome that belongs to the group of resurrection plants. Selaginella genus is known to posess a wide diversity of chemically unique molecules, especially those that make up the classes of biflavonoids and selaginellins, the latter being exclusive to their species. The present project aims to study the occurrence of secondary metabolites of pharmaceutical interest in S. convoluta, based on previous proteome data obtained from shoots and roots in desiccation and hydrated situations, with special interest in the study of the biosynthesis of secondary metabolites of pharmaceutical interest. The instrumental analysis of the proteome was performed in a UPLC DionexUltimate 3000 system with re-fragmentation of the most intense ions in a linear trap quadrupole mass spectrometer (LTQ), and the treatment of the data was carried out by the PatternLab for Proteomics software. The proteome results emphasize the preparation of the species to tolerate desiccation through coordinated mechanisms of protection and inter-organ signaling. Shoots stand out as the main organ in the biosynthesis of secondary metabolites, however it is noticeable the involvement and communication of the plant as a whole in the mobilization of enzymes present in biosynthetic pathways. In this sense, those linked to phenylpropanoid biosynthesis suggest the construction of coumarins and lignins, also showing the enzyme polyphenol oxidase, an important regulator of the phenylpropanoid pathway, as active in the synthesis of natural products in S. convoluta. The presented approaches contribute to the insertion of innovative methods in the study of molecules from Caatinga species, as well as allows the resolution of frontier issues in the study of plant species with a focus on bioactive potential molecule biosynthesis, wich promotes this exclusive biome in the highly biotechnological impact in Brazil

BANKING MEMBERS:
Externo ao Programa - 1228866 - EDUARDO LUIZ VOIGT
Externa à Instituição - IVANICE BEZERRA DA SILVA - UFC
Presidente - 1871916 - RAQUEL BRANDT GIORDANI