Banca de QUALIFICAÇÃO: RITA NYKASSIA PINHEIRO SANTOS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : RITA NYKASSIA PINHEIRO SANTOS
DATE: 31/03/2021
TIME: 14:00
LOCAL: Videoconferência
TITLE:

STUDY OF VITAMIN D ASSOCIATION WITH PREECLAMPSIA

KEY WORDS:

preeclampsia, vitamin D, biochemical markers

PAGES: 70
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Preeclampsia (PE) is a pregnancy-specific disease. It is characterized by hypertension and target-organ injury after 20 weeks of pregnancy. PE’s complications are associated with significant maternal and perinatal mortality and morbidity. Thus, understanding the development of the disease may lead to an early intervention and a more appropriated management of PE, reducing the risks to maternal and fetal/neonatal health. In this regard, there are evidence of the association of vitamin D deficiency, as well, of immunomodulatory process failure may be directly associated to PE development and evolution. Thus, the objective of the present study was to evaluate vitamin D association with PE development. Forty-five pregnant women were included: 25 with severe PE diagnosis (PE group) and 20 normotensives (normotensive group). After signing written informed consent, a fasting blood sample, to evaluate general metabolic status and 25(OH)D (25-hidroxivitamin D); and a first morning urine sample, to determine urinary albumin-to-creatinine (ACR), were collected. Regarding vitamin D evaluation, PE group was divided according to the moment of PE development in early PE group (patients who developed PE before 34th week of pregnancy) and late PE group (patients who developed PE from 34th of pregnancy); and according to the presence (PE + RH group) or not (PE group) of resistant hypertension. Regarding general metabolic status analyses, urea (p<0.001), creatinine (p<0.001), ACR (p<0.001), uric acid (p<0.001), AST (p=0.016), LDH (p=0.002), phosphorous (p=0.046) and magnesium (p<0.001) increased values, as well as, albumin (p<0.001), total protein (p<0.001) and calcium (p<0.001), diminished values, were observed in PE group when compared to the normotensives pregnant. Concerning 25(OH)D quantification, statistically lower values were observed in early PE group when compared to late PE group (p=0.045). No differences were found between the other groups. A negative correlation between 25(OH)D and ACR was also noticed (r=-0.765, p<0.001). In conclusion, pregnant women from PE group present with a biochemical profile characteristic of PE. There are also evidences that vitamin D may be associated to PE.

BANKING MEMBERS:
Presidente - 2323511 - ADRIANA AUGUSTO DE REZENDE
Externa ao Programa - 1199080 - ANA KATHERINE DA SILVEIRA GONCALVES DE OLIVEIRA
Externa ao Programa - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA