Banca de QUALIFICAÇÃO: TAMYRES BERNADETE DANTAS QUEIROGA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : TAMYRES BERNADETE DANTAS QUEIROGA
DATE: 31/03/2021
TIME: 09:00
LOCAL: Videoconferência
TITLE:

AVALIAÇÃO DE NOVAS ABORDAGENS PARA CONTROLE E DIAGNÓSTICO DA LEISHMANIOSE VISCERAL

KEY WORDS:

Visceral leishmaniasis; Control; Fluralaner; Dogs; Lutzomyia longipalpis; Leishmania infantum; Biospectroscopy; Chemometrics.

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Visceral leishmaniasis is a chronic parasitic disease with increasing geographic expansion in Brazil due to the absence of treatment thats eliminates the parasite, ineffective control actions and diagnostic methods with low accuracy. Considering this problem, this study had three main aims. The first aim was the epidemiological analysis of VL in Brazil. The second was the evaluation of systemic insecticidal efficacy of fluralaner against Lu. longipalpis as a possible control strategy and the third aim was the biospectroscopy analysis as a diagnostic method for VL in dogs serum samples and in experimental infection of Lu. longipalpis by L. infantum. This thesis was divided into chapters for better understanding. In chapter 1, SINAN data were used in the epidemiological analysis from 2008 to 2019, including cases by state, gender, age, educational level, residence area, HIV co-infection and deaths from VL. In total, 44,317 cases were reported in this period, with an annual average incidence of 1.85 per 100,000 inhabitants. Most of the cases were concentrated in the Northeast, Southeast, and North macroregions, increasing in the South. VL predominated in urban areas, in males and children under 10 years old. The incidence of VL-HIV co-infection has been increasing. Epidemiological analyses demonstrate that VL cases notification has fluctuated over the years in Brazil with greater evidence of the urbanization and territorial expansion processes. In chapter 2, mongrel dogs were recruited and randomized into two groups: fluralaner (n = 4) and control (n = 4), in order to assess the insecticidal efficacy of fluralaner, submitted to blood meal with colony-reared females of Lu. longipalpis before treatment, at day 1 post-treatment and then monthly until one year post-treatment. In the treatment group, 100% mortality of Lu. longipalpis was observed for up to five months after treatment initiation. The efficacy of fluralaner ranged from 100% at day 1 to 68% in six months, decreasing to 1.4% at one year post-treatment. Sand fly mortality fed on control dogs remained constant ≤15%. Analyses of fluralaner data suggests that the compound may be used as a possible control strategy in dogs in VL endemic areas. In chapter 3, biospectroscopy analysis as diagnosis and detection of L. infantum in the vector is in the phase of collection spectra.

BANKING MEMBERS:
Externo à Instituição - ANDREY JOSÉ DE ANDRADE - UFPR
Presidente - 323078 - LUCIA MARIA DA CUNHA GALVAO
Externo à Instituição - TATIANA MINGOTE FERREIRA DE ÁZARA - MS