Banca de DEFESA: ALESSANDRA SUELEN JARDIM DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ALESSANDRA SUELEN JARDIM DA SILVA
DATE: 26/08/2020
TIME: 09:00
LOCAL: Videoconferência
TITLE:

ESTUDOS DO DIAGNÓSTICO, CLASSIFICAÇÃO E AVALIAÇÃO PROGNÓSTICA DAS LEUCEMIAS LINFOIDE AGUDA NO RIO GRANDE DO NORTE PELA TECNOLOGIA DE IMUNOFENOTIPAGEM POR CITOMETRIA DE FLUXO

KEY WORDS:

Acute lymphoid leukemia. Immunophenotyping. Flow citometry.

PAGES: 122
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Acute Leukemia (AL) defines a huge and heterogeneous group of malignant clonal
diseases. They affect hematopoietic precursors quantitatively and qualitatively and it
needs clinical and laboratory criteria for diagnosis and classification. AL may have
myeloid or lymphoid origin and specifically for Acute Lymphoid Leukemia (ALL) it may
be subclassified in B or T lineage. In this study, 88 individuals with ALL treated at the
Hemocentro Dalton Cunha (HEMONORTE) were listed, from Rio Grande do Norte.
The patients were submitted to laboratory and immunophenotypic analyzes aiming for
outline the immunophenotypic profile of ALL in the state of Rio Grande do Norte, Brazil.
The 88 case found were between 1 month and 84 years old with a mean of 20.3 years
and 62.5% of the patients were male. The lineage most frequently observed was the
B lineage and the most evident subtype was Common Pre-B ALL. The most frequently
expressed antigens in the B subtype were CD19, CD10, HLADR and cCD79a, and the
most frequently expressed antigens in the T strain were CD7, CD5 and CD2. It was
concluded that individuals with ALL in Rio Grande do Norte have similar demographic,
clinical and immunophenotypic characteristics, as others studied around the world and
that flow cytometry immunophenotyping (FCI) is an essential way to diagnose AL of
lymphoid origin.

BANKING MEMBERS:
Externa ao Programa - 1375489 - ANA CLAUDIA GALVAO FREIRE GOUVEIA
Presidente - 6349161 - GERALDO BARROSO CAVALCANTI JUNIOR
Externo à Instituição - GUSTAVO HENRIQUE DE MEDEIROS OLIVEIRA - HEMONORTE