Banca de DEFESA: FABÍOLA LEITE GOUVEIA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : FABÍOLA LEITE GOUVEIA
DATE: 20/07/2020
TIME: 10:00
LOCAL: Videoconferência
TITLE:

Evaluation of the effect of coenzyme-q10 supplementation on insulin resistance in obese women with polycystic ovarian syndrome.

KEY WORDS:

Polycystic Ovary Syndrome. Coenzyme Q10. Insulin resistance.

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Polycystic Ovarian Syndrome (PCOS) is an endocrinopathy of multifactorial cause, undefined
origin and affecting a considerable portion of the female population of reproductive age. Due
to its characteristic metabolic profile, it can present dyslipidemia, obesity, metabolic
syndrome (MS) and insulin resistance (IR), these factors can contribute to the development of
oxidative stress (OES). This OES generated by excess reactive oxygen species favors the
development of complications such as atherosclerosis, inflammatory and cardiac diseases,
among others. Considering this fact, coenzyme Q10 is a benzoquinone that plays an important
role in the elimination of free radicals and inhibition of lipid and protein oxidation. Therefore,
this study aimed to evaluate the effect of coenzyme Q10 supplementation on insulin resistance
in obese women with PCOS. The study population was composed of 60 obese women aged
20 to 40 years with and without the diagnosis of PCOS. For comparative analysis, the patients
were divided into two groups: Case (obese with PCOS - n = 30); Control (obese without SOP
- n = 30), and submitted to supplementation with coenzyme Q10 100mg/day orally for 8
weeks. Obesity was characterized by body mass index (BMI), the cut point being ≥ 30.0
kg/m². In follow-up, women were evaluated regarding clinical, biochemical and hormonal
parameters. Statistical analysis of the data was performed with the statistical package SPSS©
22. IR was present in 76.7% of the case group and 80% of the control group. The comparative
analysis between the PCOS pre and post intervention group showed significant differences in
relation to mass (91.1 vs. 89.9 kg p=0.008), glucose 120 minutes (138 vs. 122.5 mg/dL
p=0.004), insulin (16.2 vs. 10.7 μUI/mL p=0.000), HOMA-IR (3.67 vs. 2.31 p=0.000) and
QUICKI (0.31 vs. 0.30 p=0.000). In addition, significant changes were observed in the
hormone profile, such as follicle stimulating hormone (5.4 vs. 6.0 IU/mL p=0.004),
luteinizing hormone (6.3 vs. 4.5 IU/mL p=0.000), testosterone (32.1 vs. 22.0 ng/dL p=0.000)
and progesterone (0.20 vs. 0.35 ng/dL p=0.000). In relation to the control group (post
suplementation), it was possible to observe significant results in relation to biochemical and
hormonal parameters. Thus, intervention with coenzyme Q10 may promote beneficial effects
in relation to the main metabolic and hormonal changes that are present in PCOS and obesity.

BANKING MEMBERS:
Interna - 1055045 - MARCELA ABBOTT GALVAO URURAHY
Externa à Instituição - MELINA BEZERRA LOUREIRO - UnP
Presidente - 1306690 - TELMA MARIA ARAUJO MOURA LEMOS