Banca de QUALIFICAÇÃO: EDNALDO GOMES DO NASCIMENTO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : EDNALDO GOMES DO NASCIMENTO
DATE: 31/03/2020
TIME: 09:00
LOCAL: SALA 2 DO PPGCF
TITLE:

Physico-chemical properties and evaluation of the release behavior of triamcinolone acetonide complexed with solubilizing agents in chitosan membranes

KEY WORDS:

triamcinolone acetonide, chitosan membranes, cyclodextrin, aphthous stomatitis, controlled drug release.

PAGES: 126
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Triamcinolone is a corticosteroid used to treat topical ulcerations. Despite its use in topical therapy, it presents problems of solubility making it difficult to use in oral and topical dosage forms. Solubilizing agents, such as cyclodextrins and triethanolamine can promote better solubility of this drug, while the chitosan membrane allows incorporating assets and modifying their release, modulating their biopharmaceutical profile. The aim of the present work was to develop chitosan membranes capable of incorporating multicomponent systems with sustained release of triamcinolone acetonide, to promote the possible treatment of minor recurrent aphthous stomatitis. The chitosan membranes were developed using the solvent evaporation method (casting), in which the incorporation of triamcinolone acetonide was carried out through the previous dispersion of this drug in HPBCD or BCD solutions (binary systems) containing or not triethanolamine (ternary system). The membranes were characterized by atomic force microscopy (AFM), scanning electron microscopy (SEM-FEG), absorption spectroscopy in the infrared region with Fourier transform (FTIR), percentage of swelling, surface pH measurements, X-ray diffraction (DRX), tensile test and thermal analysis (DSC and ATG / DTG). All the proposed systems developed had similar physical-chemical characteristics. The in vitro release performance test for triamcinolone acetonide was carried out on cells of the Franz type, obtaining a quantity released that varied from 56 to 273 ìg / mL after the 24h period. The quantification released for triamcinolone was done by ultra-performance liquid chromatography (UPLC). Of the kinetic mathematical models used, Bhaskar and parabolic diffusion best represented the release behavior of the studied systems. Among the systems developed and evaluated, incorporating triamcinolone in the chitosan membranes in the form of a ternary system was more promising as a sustained release system.

BANKING MEMBERS:
Presidente - 1492900 - CICERO FLAVIO SOARES ARAGAO
Externo ao Programa - 2195251 - HUGO ALEXANDRE DE OLIVEIRA ROCHA
Externa ao Programa - 2203888 - MARCIA RODRIGUES PEREIRA