Banca de QUALIFICAÇÃO: SARA IASMIN VIEIRA CUNHA LIMA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : SARA IASMIN VIEIRA CUNHA LIMA
DATA : 26/06/2019
HORA: 15:00
LOCAL: SALA 1 DO PPGCF
TÍTULO:

PREVISÃO DE OCORRÊNCIA DE REAÇÃO ADVERSA A MEDICAMENTO
EM PACIENTES HOSPITALIZADOS

PALAVRAS-CHAVES:

Adverse drug reaction; Risk factors; Pharmacovigilance; Risk score.

PÁGINAS: 66
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Introduction: ADRs have a significant incidence among hospitalized patients. An
important step in reducing the incidence of adverse reactions would be to
identify those patients who are at increased risk of developing an ADR from
individual risk factors. Objective: Develop a tool to predict adverse drug
reactions in hospitalized patients. Methodology: Observational, analytical, casecontrol
study in a 1: 2 ratio of all patients admitted during the period from June
2016 to December 2017 at Hospital Universitário Onofre Lopes, Brazil. For the
identification of the variables of the patients associated with the occurrence of
ADR, the univariate analysis of each patient variable by conditional logistic
regression was performed initially with the entire study population. For the
multivariate analysis were included the variables that in univariate analysis
showed a significant association with the occurrence of ADR at a level of
significance <0.10. The statistical program Stata 12 was used. Results: The
proportion of patients with one or more ADRs was 4.43% (95% CI 4.00 to
4.90%). The most common adverse reactions were hypoglycaemia (26.4%) and
hypotension (15.2%). Univariate analysis identified 27 variables that were
associated with the occurrence of ADR. Twelve variables were statistically
related to the occurrence of ADR, such as female (adjusted OR, 1.61, 95% CI,
1.18-2.21), previous history of ADR (ORA 1.97 CI 95 (ORA 1.63 95% CI 1.13-
2.34) and with target organ damage (ORA 6.49, 95% CI, 3.56-11.83) and
intravenous drug prescription (ORA 1.60, 95% CI, 1.14-2.24). Conclusion: The
prevalence of ADR was observed in 3.97% of the patients, with emphasis on
dose-dependent hypoglycemia and hypotension reactions. Twelve independent
risk factors for ADR development were identified, with diabetes with target
organ damage being the most impacting factor. Based on these factors, the risk
assessment tool for the development of ADR was developed and validated.

MEMBROS DA BANCA:
Presidente - 1893445 - EUZEBIO GUIMARAES BARBOSA
Externa à Instituição - FRANCISCA SUELI MONTE MOREIRA - UFPE
Interna - 1055045 - MARCELA ABBOTT GALVAO URURAHY