Banca de DEFESA: SHAYANNE MOURA FERNANDES DE ARAUJO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : SHAYANNE MOURA FERNANDES DE ARAUJO
DATA : 26/03/2019
HORA: 14:00
LOCAL: SALA 2 DO PPGCF
TÍTULO:

Correlation of serum vitamin D levels with factors associated with Polycystic Ovarian Syndrome

PALAVRAS-CHAVES:

Polycystic Ovarian Syndrome. Hypovitaminosis D. Endocrinopathy.

PÁGINAS: 72
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Polycystic ovarian syndrome (PCOS) is considered the most common endocrinopathy in the reproductive phase of women, with a prevalence of up to 26%, as well as being the major cause of infertility among women. In general, PCOS is the most common cause of anovulation and evidence suggests that vitamin D deficiency has been associated with fertility, adipogenesis, insulin resistance, diabetes and obesity which may be primary factors in the development of PCOS. The aim of this study was to evaluate serum vitamin D levels in women with polycystic ovary syndrome (PCOS) and its associated factors. The study population consisted of 100 women with PCOS, aged between 18 and 40 years. For the clinical variables, a Pearson correlation test was performed to evaluate the possible relationships of serum vitamin D values with the other study variants. The tests were considered statistically significant at p <0.05. The mean age of the study participants was (26.74 ± 5.52) and BMI (30.07 ± 5.37 kg / m2). Most of the women were obese and overweight (47%) and (39%). In relation to the modified Ferriman-Gallwey score, the mean was (11.95 ± 5.96), presenting a mean of high score for hirsutism and (55%) presented infertility. In relation to hypovitaminosis, the frequency was 57% (failure 49% and deficiency 8%). In the static analysis, the fertility (r=0.209, p=0.03*), gynoid fat (r= -0.225, p=0.04*) and urea (r=-0.206, p=0.04*). Adequate values of vitamin D may improve ovulatory dysfunction and thus fertility in women with the syndrome. This can be explained by the finding that VDR was found in several tissues of the female reproductive system, such as ovaries, placenta and endometrium, and 1,25 (OH) D directly leads to the production of estrogen and progesterone in the ovaries. Vitamin D levels vary with body mass in PCOS, many studies have reported inverse associations between body fat and serum levels of 25OHD. It is believed that the high prevalence of hypovitaminosis D in women with PCOS is related to obesity, as vitamin D is fat-soluble and in obesity, a higher proportion is sequestered in adipose tissue, thus decreasing bioavailability. Considering the results, it can be observed that the socio-demographic profile of the volunteers remained similar when compared to previous studies of PCOS, the majority of the women presented obesity, mainly android, more than half of the women presented infertility and even with the climate in the northeast, had a mean of hypovitaminosis D, which may be a risk factor for PCOS, since it is part of glucose homeostasis and in modulating the insulin receptor response. We observed a statistical correlation of vitamin D status with fertility, gynoid fat and urea, where there is room for vitamin D supplementation to help improve ovulatory parameters.

MEMBROS DA BANCA:
Presidente - 1306690 - TELMA MARIA ARAUJO MOURA LEMOS
Externa ao Programa - 2315640 - MARCIA MARILIA GOMES DANTAS LOPES
Externa à Instituição - AMALIA CINTHIA MENESES DO REGO - UnP